tenascin X

MW over 400 kDa; closely resembles tenascin; expressed in fetal tissue; XB-S is a novel transcript found in adrenal gland; corresponds to the carboxy-terminal 673 residues of tenascin-X; has the same open reading frame as TN-X; RefSeq NM_032470 (human); NM_031176 (mouse)

Also Known As:

TNXB protein, human; Tnxb protein, mouse; XB-S protein, human; short XB protein, human; tenascin XB protein, human; tenascin XB protein, mouse; tenascin-X

Networked: 89 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Scleroproteins: 74
    - Extracellular Matrix Proteins: 3148
      - Tenascin: 1719
        tenascin X: 89

Experts

1.	Matsumoto, Ken-Ichi: 10 articles (01/2021 - 09/2002)
2.	Schalkwijk, Joost: 10 articles (10/2020 - 04/2004)
3.	Schalkwijk, J: 9 articles (01/2017 - 10/2001)
4.	Merke, Deborah P: 7 articles (10/2019 - 02/2013)
5.	Morissette, Rachel: 5 articles (01/2016 - 02/2013)
6.	Chiquet-Ehrismann, Ruth: 5 articles (01/2012 - 07/2003)
7.	McDonnell, Nazli B: 4 articles (08/2015 - 02/2013)
8.	Voermans, Nicol C: 4 articles (04/2012 - 09/2010)
9.	Zweers, Manon C: 4 articles (04/2006 - 04/2004)
10.	Zweers, M C: 4 articles (03/2006 - 10/2001)

Related Diseases

1.	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 01/01/2023 - "Classical-like Ehlers-Danlos syndrome (clEDS) is an autosomal recessive disorder caused by complete absence of tenascin-X resulting from biallelic variation in TNXB. " 01/01/2023 - "Tenascin-X as a causal gene for classical-like Ehlers-Danlos syndrome." 01/01/2022 - "Classical-like Ehlers-Danlos syndrome (clEDS) is the result of tenascin-X deficiency due to biallelic loss of function variants in the TNXB gene. " 01/01/2022 - "Therefore, the patient was diagnosed as a tenascin-X (TNX) deficient type of EDS known as classical-like Ehlers-Danlos syndrome. " 10/01/2020 - "Biallelic Tenascin-X mutations cause classical-like Ehlers-Danlos syndrome. "
2.	Neoplasms (Cancer) 05/01/2020 - "Loss of Tenascin-X expression during tumor progression: A new pan-cancer marker." 11/01/2002 - "Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion." 05/01/1997 - "Tenascin-X (TN-X) is the latest member of the TN family to be reported, and its expression in tumor tissues has not yet been examined. " 08/01/1996 - "Tenascin-X expression in tumor cells and fibroblasts: glucocorticoids as negative regulators in fibroblasts." 11/01/2009 - "Our data suggest that tenascin-X may be a new diagnostic marker of malignant mesothelioma in the differential diagnosis of cancers involving the serosal cavities, particularly in the differential diagnosis between this tumor and ovarian/peritoneal serous carcinoma."
3.	Neoplasm Metastasis (Metastasis) 12/01/2001 - "Tumour invasion and metastasis are promoted in mice deficient in tenascin-X." 07/15/2004 - "The results of our previous study showed that tumor invasion and metastasis are promoted in extracellular matrix (ECM) tenascin-X-deficient (TNX-/-) mice via increased expression of matrix metalloproteinases (MMPs). " 11/01/2002 - "Extracellular matrix tenascin-X (TNX)-null mice, generated by disruption of the Tnx gene, display augmented invasion and metastasis of B16-BL6 melanoma tumor cells due to increased activities of matrix metalloproteinase (MMP)-2 and MMP-9. "
4.	Abdominal Aortic Aneurysm 04/04/2006 - "In this study, we investigated whether tenascin-X is present in normal human aorta and abdominal aortic aneurysm (AAA) tissues and whether an association exists between serum tenascin-X levels and AAA. " 01/01/2010 - "Increased expression of tenascin-x in thoracic and abdominal aortic aneurysm tissues." 04/04/2006 - "Abdominal aortic aneurysm is associated with high serum levels of tenascin-X and decreased aneurysmal tissue tenascin-X."
5.	Schizophrenia (Dementia Praecox) 01/23/2004 - "A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. " 12/29/2009 - "Tenascin-X (Tn-X) belongs to the tenascin family of glycoproteins and has been reported to be significantly associated with schizophrenia in a single nucleotide polymorphism analysis in humans. "

Related Drugs and Biologics

1.	Tenascin
2.	Collagen
3.	Proteins (Proteins, Gene)
4.	Matrix Metalloproteinases (MMPs)
5.	Messenger RNA (mRNA)
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Cytokines
8.	Osteonectin
9.	Glycoproteins (Glycoprotein)
10.	Extracellular Matrix Proteins

Related Therapies and Procedures

1.	Hip Replacement Arthroplasty (Total Hip Replacement)
2.	Lasers (Laser)