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2,6- dimethoxyhydroquinone- 3- mercaptoacetic acid

an antineoplastic agent that can be carried to its target by small cyclic peptides

Also Known As:

DMQ-MA; Acetic acid, ((3,6-dihydroxy-2,4-dimethoxyphenyl)thio)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroquinones: 47
        2,6-dimethoxyhydroquinone-3-mercaptoacetic acid: 2

Experts

1.	Song, Y F: 1 article (11/2001)
2.	Yang, P: 1 article (11/2001)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2001 - "This paper reports on an ongoing study of the use of short chain peptides as carriers of a potential anti-tumor agent: 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). " 11/01/2001 - "In an effort to carry out anti-cancer drug design, we synthesized three new peptide-DMQ-MA conjugates: DMQ-MA-Arg-Arg-Ome, DMQ-MA-Lys(Cbz)-Arg-Ome, DMQ-MA-Lys(Cbz)-Arg-Arg-Ome; two new DMQ-MA-peptide-Chlorambucil (CRB) derivatives: DMQ-MA-Lys(CRB)-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Lys(CRB)-Arg-Ome and four tripeptide-cytotoxic agent conjugates: DMQ-MA-Lys(DMQ-MA)-Phe-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Ile-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Val-Arg-Ome, DMQ-MA-Lys(DMQ-MA)-Lys(Cbz)-Arg-Ome. "
2.	Carcinoma (Carcinomatosis) 07/01/1998 - "The IC50 of the cyclic tripeptide-DMQ-MA conjugates against a human pulmonary carcinoma cell line (PC-9 cells) under the synergistic activation of AH2 ranges from 0.4 to 1.6 microM, which is significantly lower than the parent compound DMQ-MA (6.1 microM). "

Related Drugs and Biologics

1.	2,6- dimethoxyhydroquinone- 3- mercaptoacetic acid
2.	Peptides (Polypeptides)
3.	Cytotoxins (Cytolysins)
4.	Chlorambucil (Leukeran)
5.	arginylarginine (Arg-Arg)
6.	phenylalanylarginine