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9- (2',3'- dihydroxycyclopentan- 1'- yl)adenine

inhibitor of S-adenosylhomocysteine hydrolase; structure given in first source

Also Known As:

DHCaA

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        9-(2',3'-dihydroxycyclopentan-1'-yl)adenine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - 9-(2',3'-dihydroxycyclopentan-1'-yl)adenine: 1
  - Ribonucleosides: 49
    - Adenosine: 12431
      - 9-(2',3'-dihydroxycyclopentan-1'-yl)adenine: 1

Experts

1.	Conner, E M: 1 article (01/2001)
2.	Saso, Y: 1 article (01/2001)
3.	Teegarden, B R: 1 article (01/2001)
4.	Yuan, C S: 1 article (01/2001)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2001 - "A specific and potent inhibitor of S-adenosyl-L-homocysteine (AdoHcy) hydrolase, 9-[(1'R,2'S,3'R)-2', 3'-dihydroxycyclopentanyl]adenine (DHCaA), was evaluated for its immunosuppressive efficacy on murine T-cell proliferation in vitro and in several animal models, including delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis. "
2.	Arthritis (Polyarthritis) 01/01/2001 - "In rat peptidoglycan polysaccharide-induced arthritis, orally dosed DHCaA significantly suppressed inflamed paw volumes with minimal effective dose of 0.1 mg/kg. At a dose of 1 mg/kg, DHCaA almost completely inhibited paw swelling. " 01/01/2001 - "A specific and potent inhibitor of S-adenosyl-L-homocysteine (AdoHcy) hydrolase, 9-[(1'R,2'S,3'R)-2', 3'-dihydroxycyclopentanyl]adenine (DHCaA), was evaluated for its immunosuppressive efficacy on murine T-cell proliferation in vitro and in several animal models, including delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis. "

Related Drugs and Biologics

1.	Polysaccharides (Glycans)
2.	Peptidoglycan (Murein)
3.	Hydrolases
4.	Homocysteine
5.	Adenine