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1- (1',3',4'- trihydroxy- 2'- butoxy)methyl- 2- nitroimidazole
a 2-nitroimidazole nucleoside analog; used as a hypoxic cell sensitizer
Also Known As:
RP 343; RP-343; 1,2,4-Butanetriol, 3-((2-nitro-1H-imidazol-1-yl)methoxy)-, (R*,S*)-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitro Compounds: 66
Nitroimidazoles: 565
1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Nitroimidazoles: 565
1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole: 1
Carbohydrates: 22023
Glycosides: 2119
Nucleosides: 6847
1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole: 1
Related Diseases
1.
Neoplasms (Cancer)
06/15/1993 - "
While having the lowest partition coefficient (0.035), RP-343 exhibited almost equally effective distribution to tumors and sensitizing radiation activity.
"
06/15/1993 - "
The maximum tumor concentration/AUC for brain (Cmax,tumor/AUCbrain) ratios for RP-343 and RP-170 were 9.62 and 3.98.
"
06/15/1993 - "
At the same toxicity levels, RP-343 was found to have better sensitization of solid tumors over both etanidazole and RP-170.
"
06/15/1993 - "
An intravenous (i.v.) injection of 100 mg/kg of RP-343, RP-170 and etanidazole showed an almost equal sensitizer enhancement ratio (SER) of about 1.4 to solid EMT6 tumor under in vivo-in vitro assay and a virtually equal SER of 1.33-1.44 to solid SCCVII tumor under both tumor growth delay assay and TCD50 assay.
"
Related Drugs and Biologics
1.
Etanidazole
2.
RP 170