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jadomycin B

structure given in first source; isolated from Streptomyces venezuelae

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - jadomycin B: 7

Experts

1.	Yang, Ke-Qian: 2 articles (08/2008 - 06/2005)
2.	Zheng, Jian-Ting: 2 articles (08/2008 - 06/2005)
3.	Fu, Da-Hua: 1 article (08/2008)
4.	Jiang, Jian-Dong: 1 article (08/2008)
5.	Jiang, Wei: 1 article (08/2008)
6.	Li, Yan: 1 article (08/2008)
7.	Li, Zhuo-Rong: 1 article (08/2008)
8.	Si, Shu-Yi: 1 article (08/2008)
9.	Wang, Yanchang: 1 article (08/2008)
10.	Yi, Hong: 1 article (08/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2022 - "In conclusion, jadomycin B demonstrated a good safety profile and provided partial anti-tumoral effects, warranting further dose-escalation safety and efficacy studies in MDR breast cancer models." 04/01/2023 - "Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models." 11/01/2022 - "Jadomycin B, a natural product derived from Streptomyces venezuelae ISP5230, maintains cytotoxicity in MDR human breast cancer cells. " 11/01/2022 - "Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models."
2.	Shock 09/01/2006 - "We have modified the culture conditions by altering the carbon source, buffer, inoculum size, and timing of ethanol shock, thereby reducing growing times and improving jadomycin B production. " 09/01/2006 - "Our optimized conditions use glucose as the carbon source, MOPS as buffer, low concentrations of phosphate, a defined inoculum concentration and an immediate ethanol shock to induce jadomycin B production; results that contrast previous studies. "
3.	Neoplasms (Cancer) 08/01/2008 - "We also present evidence suggesting that Jadomycin B induces apoptosis in tumor cells without obvious effects on cell cycle. " 06/01/2005 - "Cytotoxic activities of jadomycin B and five new jadomycin derivatives against four cancer cell lines (HepG2, IM-9, IM-9/Bcl-2 and H460) were evaluated. " 11/01/2022 - "In the 4T1 mouse mammary carcinoma model, jadomycin B (12 mg/kg every 12 h from day 6 to 15 after tumor cell injection) decreased primary tumor volume compared to vehicle control. " 01/01/2023 - "We searched Pubmed, Scopus, NLM, Pubchem, and Relemed to obtain information pertinent to the updated signaling role of aurora kinases and medicinal chemistry approaches and discussed the recently updated roles of each aurora kinases and their downstream signaling cascades in the progression of several chemosensitive/chemoresistant cancers; subsequently, we discussed the natural products (scoulerine, Corynoline, Hesperidin Jadomycin-B, fisetin), and synthetic, medicinal chemistry molecules as aurora kinase inhibitors (AKIs). "
4.	Weight Loss (Weight Reduction) 11/01/2022 - "Jadomycin B-treated mice did not exhibit weight loss, nor significant increases in biomarkers of impaired hepatic (alanine aminotransferase) and renal (creatinine) function. "
5.	Infections 03/01/1994 - "Among other heat-shock inducing treatments examined, infection with phage SV1 was associated with increased jadomycin B production. " 03/01/1994 - "Conditions for the production of jadomycin B by Streptomyces venezuelae ISP5230: effects of heat shock, ethanol treatment and phage infection."

Related Drugs and Biologics

1.	Ethanol (Ethyl Alcohol)
2.	Phosphates (Orthophosphate)
3.	Glucose (Dextrose)
4.	Carbon
5.	Buffers
6.	morpholinopropane sulfonic acid (MOPS)
7.	Aurora Kinases
8.	Biomarkers (Surrogate Marker)
9.	Hesperidin
10.	Creatinine