bis(MSH)-DTPA

two complete MSH peptide sequences linked via their N'-termini to a single molecule of DTPA; used as an imaging agent for malignant melanoma

Also Known As:

bisMSH-DTPA

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Pentetic Acid: 1751
      - bis(MSH)-DTPA: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Pentetic Acid: 1751
        bis(MSH)-DTPA: 2
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Pituitary Hormones: 601
      - Anterior Pituitary Hormones: 187
        Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
      - Hypothalamic Hormones: 68
        Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
- Peptides: 82426
  - Neuropeptides: 6772
    - Melanocyte-Stimulating Hormones: 1119
      - bis(MSH)-DTPA: 2
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
  - Peptide Hormones: 1347
    - Pituitary Hormones: 601
      - Anterior Pituitary Hormones: 187
        Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2
    - Hypothalamic Hormones: 68
      - Pro-Opiomelanocortin: 1936
        Melanocortins: 946
        Melanocyte-Stimulating Hormones: 1119
        bis(MSH)-DTPA: 2

Related Diseases

1.	Melanoma (Melanoma, Malignant) 12/01/1990 - "We conclude that bisMSH-DTPA may offer an alternative to antibody targeting in the imaging of malignant melanoma." 02/01/1992 - "A novel chelating derivative of alpha melanocyte stimulating hormone, bis MSH-DTPA, has been used for the diagnostic targeting of malignant melanoma. " 12/01/1990 - "When DBA/2 mice bearing the same tumour were injected with bisMSH-DTPA labelled with the gamma-emitting isotope indium-111 (111In), the radioactivity became rapidly associated with the melanoma tissue. "
2.	Experimental Melanoma 12/01/1990 - "This compound, bisMSH-DTPA, was equipotent with MSH in an in vitro tyrosinase assay with Cloudman S91 melanoma cells. "

Related Drugs and Biologics

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Melanocyte-Stimulating Hormones (MSH)
3.	Isotopes
4.	alpha-MSH
5.	Indium-111