monoclonal antibody ZCE 025

a commercially available IgG(1) antibody against carcinoembryonic antigen (CEA); MW 150 kDa; Altumomab pentetate is the USAN assigned name to the monoclonal conjugate (CAS RN 139039-69-3)

Also Known As:

Networked: 25 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adelstein, Stephen: 1 article (11/2021)
2.	Lang, Bethan: 1 article (11/2021)
3.	Urriola, Nicolás: 1 article (11/2021)
4.	Gou, Lin: 1 article (01/2013)
5.	Li, Jie: 1 article (01/2013)
6.	Li, Zhuyi: 1 article (01/2013)
7.	Liu, Rui: 1 article (01/2013)
8.	Miao, Jianting: 1 article (01/2013)
9.	Wang, Guiping: 1 article (01/2013)
10.	Xu, Hanpeng: 1 article (01/2013)

Related Diseases

1.	Neoplasms (Cancer) 02/15/1996 - "Absolute tumor accumulation seen with the trivalent construct (10.8% injected dose/g) was lower than that seen with the intact MAb35 (15.2% injected dose/g). " 12/01/1993 - "The results showed that the 67Cu-labeled intact MAb35 achieved twice the percentage of injected dose/g tumor when compared to its 131I-labeled counterpart, without significant impairment of the wholebody distribution pattern. " 07/01/1990 - "These results suggest an important role for 111In-labeled ZCE-025 scanning among patients with rising CEA and otherwise occult metastatic cancer." 07/01/1990 - "In all seven, cancer was subsequently detected at the sites suggested by the ZCE-025 scan. " 02/15/1996 - "These improvements were achieved despite only modest reduction in maximum tumor accumulation when compared to the parent MAb35, and this augurs well for an improved potential for this novel construct as an agent for radioimmunotherapy and radioimmunoscintigraphy."
2.	Colorectal Neoplasms (Colorectal Cancer) 06/01/1997 - "Biokinetics of simultaneously injected 67Cu- and 125I-labeled MAb35 were studied in six patients scheduled for surgery of primary colorectal cancer. " 09/01/1991 - "[Immunoscintigraphy of colorectal cancer with 111In labeled anti-CEA monoclonal antibody (ZCE-025)]." 07/01/1990 - "111In-labeled anti-CEA MoAb ZCE-025 scanning in patients with rising CEA successfully imaged metastatic colorectal cancer that eluded detection by other methods and affected the care given to some. " 08/01/1988 - "One milligram of 111In-labeled ZCE-025 antibody coinfused with 39 mg of unlabeled antibody appeared optimal for detecting metastatic colorectal cancer, particularly in the liver. " 09/01/1991 - "Five patients with colorectal cancer suspected were given an intravenous injection of 1 mg of 111In labeled ZCE-025. "
3.	Lymphatic Metastasis 09/01/1987 - "Because of the high detection rate of lymph node metastases from colorectal carcinoma with In-111 ZCE-025, this technique may be helpful in preoperative staging of patients with colorectal tumors, as well as in distinguishing recurrent tumors from postoperative or postradiation changes seen on computed tomography scans or other radiologic images."
4.	Neoplasm Metastasis (Metastasis) 09/01/1987 - "Twenty-five percent of liver metastases exhibited positive accumulation of In-111 ZCE-025 at doses of 40-80 mg. No side effects were encountered. " 02/01/1990 - "ZCE-025 monoclonal antibody imaging detected tumor recurrence or metastasis in 11 of 13 patients. " 07/01/1990 - "Imaging with indium111-labeled anticarcinoembryonic antigen monoclonal antibody ZCE-025 of recurrent colorectal or carcinoembryonic antigen-producing cancer in patients with rising serum carcinoembryonic antigen levels and occult metastases."
5.	Colonic Neoplasms (Colon Cancer) 10/01/1988 - "A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. " 07/01/1990 - "Twenty patients with a history of completely resected CEA-producing adenocarcinoma (18 with colon cancer, one with breast cancer, and one with Hodgkin's disease) and a rising serum CEA level were given an intravenous infusion of 2 mg of 111In-labeled ZCE-025 mixed with 38 mg of unlabeled ZCE-025. " 08/01/1988 - "We have evaluated immunoscintigraphy in cancer patients using four 111In-labelled murine monoclonal antibodies (MoAb): 96.5 (anti-P97 of melanoma), ZME-018 (anti-high molecular weight antibody of melanoma), ZCE-025 (anti-CEA for colon cancer) and PAY-276 (anti-prostatic acid phosphatase for prostatic cancer). "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Carcinoembryonic Antigen
3.	Immunoglobulin G (IgG)
4.	Indicators and Reagents (Reagents)
5.	Glycoproteins (Glycoprotein)
6.	Antigens
7.	Indium-111
8.	Indium
9.	Conotoxins (Conotoxin)
10.	Cholinergic Receptors

Related Therapies and Procedures

1.	Radioimmunotherapy
2.	Gamma Cameras (Gamma Camera)
3.	Intravenous Injections
4.	Intravenous Infusions