arachidonyltrifluoromethane

structure given in first source; inhibits 85-kDa phospholipase A2

Also Known As:

6,9,12,15-heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)-; AACOCF3; AN-20579; ATFMK; BM-162353; L-734575; arachidonic acid trifluoromethyl ketone; arachidonyl trifluoromethyl ketone

Networked: 33 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        arachidonyltrifluoromethane: 33
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        arachidonyltrifluoromethane: 33

Experts

1.	Chen, Pengxiang: 1 article (04/2022)
2.	Cheng, Bo: 1 article (04/2022)
3.	Cheng, Yufeng: 1 article (04/2022)
4.	Liu, Hui: 1 article (04/2022)
5.	Liu, Tianyu: 1 article (04/2022)
6.	Liu, Yuchen: 1 article (04/2022)
7.	Sun, Changhua: 1 article (04/2022)
8.	Wen, Zhihua: 1 article (04/2022)
9.	Xin, Huixian: 1 article (04/2022)
10.	Agarwal, Pranay: 1 article (02/2022)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 09/01/2011 - "Arachidonyl trifluoromethyl ketone ameliorates experimental autoimmune encephalomyelitis via blocking peroxynitrite formation in mouse spinal cord white matter."
2.	Hyperalgesia 09/01/2007 - "Consistent with these findings, AACOCF3 reduced the development of both thermal hyperalgesia and mechanical allodynia, whereas diclofenac exacerbated thermal hyperalgesia, in CCI rats. " 04/01/2005 - "Secondly, we showed that intrathecal (i.t.) administration of MAFP and AACOCF3, but not BEL, dose-dependently prevented thermal hyperalgesia induced by intraplantar carrageenan as well as formalin-induced flinching. " 11/01/2004 - "The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice. " 01/01/2017 - "Hyperalgesia was inhibited by the pretreatment of the animals with cyclooxygenase inhibitor indomethacin, with type-2 cyclooxygenase inhibitor celecoxib, with AACOCF3 and PACOCF3, inhibitors of cytosolic and Ca2+-independent PLA2s, respectively, with bradykinin B2 receptor antagonist HOE 140, with antibodies against TNFα, IL-1β, IL-6 and CINC-1 and with selective ET-A (BQ-123) and ET-B (BQ-788) endothelin receptors antagonists. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 08/01/2009 - "Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury." 01/01/2021 - "Surviving motoneurons undergo dendritic atrophy after spinal cord injury (SCI), suggesting an important therapeutic target for neuroprotective strategies to improve recovery of function after SCI. Our previous studies showed that cytosolic phospholipase A2 (PLA2) may play an important role in the pathogenesis of SCI. In the present study, we investigated whether blocking cytosolic PLA2 (cPLA2) pharmacologically with arachidonyl trifluoromethyl ketone (ATK) or genetically using cPLA2 knockout (KO) mice attenuates motoneuron atrophy after SCI. C57BL/6 mice received either sham or contusive SCI at the T10 level. "
4.	Stroke (Strokes) 08/30/2012 - "The object of this study was to determine the effect of cPLA(2)α inhibition with arachidonyl trifluoromethyl ketone (ATK) on stroke injury in mice. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/20/2017 - "Several compounds were found to inhibit cPLA2 more strongly than arachidonyl trifluoromethyl ketone (AACOCF3), an inhibitor that is commonly used in the study of cPLA2-related neurodegenerative diseases. "

Related Drugs and Biologics

1.	Peroxynitrous Acid (Peroxynitrite)
2.	arachidonyltrifluoromethane
3.	Phospholipases A2 (Phospholipase A2)
4.	6- (bromomethylene)tetrahydro- 3- (1- naphthaleneyl)- 2H- pyran- 2- one
5.	Calcium-Independent Phospholipases A2
6.	Secretory Phospholipases A2
7.	Carrageenan
8.	Protein Isoforms (Isoforms)
9.	salicylhydroxamic acid (SHAM)
10.	Calcium

Related Therapies and Procedures

1.	Therapeutics
2.	Spinal Injections
3.	Contact Lenses