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3,3'-diethyloxacarbocyanine

inhibits bovine heart mitochondrial NADH oxidase activity; structure given in first source; RN given refers to parent cpd

Also Known As:

3,3'-diethyloxacarbocyanine iodide; DiOC2; DiOC2(3)

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkynes: 217
      - Carbocyanines: 74
        3,3'-diethyloxacarbocyanine: 4

Experts

1.	Amaral, Leonard: 1 article (01/2016)
2.	Armada, Ana: 1 article (01/2016)
3.	Martins, Célia: 1 article (01/2016)
4.	Molnar, Joseph: 1 article (01/2016)
5.	Rodrigues, António Sebastião: 1 article (01/2016)
6.	Spengler, Gabriella: 1 article (01/2016)
7.	Viveiros, Miguel: 1 article (01/2016)
8.	Chan, Ya-Ching: 1 article (08/2012)
9.	Chang, Fang-Rong: 1 article (08/2012)
10.	Chang, Hsueh-Wei: 1 article (08/2012)

Related Diseases

1.	Lymphoma (Lymphomas) 01/01/2016 - "The use of ABCB1-transfected mouse T-lymphoma cell line to study the uptake/efflux of fluorescent probes like ethidium bromide (EB), rhodamine 123 (Rh-123), and carbocyanine dye DiOC2, in the presence and absence of potential inhibitors, is currently used in our laboratories to evaluate the ability of a drug to inhibit ABCB1-mediated drug accumulation and efflux. "
2.	Neoplasms (Cancer) 08/31/2012 - "The DiOC2(3) intensity for mitochondrial membrane potential (MMP) of MEGT-treated Ca9-22 cancer cells was significantly decreased in a dose-response manner (p < 0.05). " 01/01/2016 - "Here we describe and compare three in vitro methods, which evaluate the permeability, transport kinetics of fluorescent substrates, and inhibition of the ABCB1 efflux pump by drugs of chemical synthesis or extracted from natural sources, using model cancer cell lines overexpressing this transporter, namely (1) real-time fluorimetry that assesses the accumulation of ethidium bromide, (2) flow cytometry, and (3) fluorescent microscopy using rhodamine 123 and DiOC2. "
3.	Ganglion Cysts (Ganglion) 01/05/1996 - "Synaptic transmission from single preganglionic hypogastric nerves innervating monopolar pelvic ganglion neurones has been studied with intracellular electrodes to record transmission from all the boutons and with extracellular electrodes placed over boutons visualized with DiOC2(5) in order to record transmission from selected boutons. "
4.	Phototoxic Dermatitis (Phototoxicity) 01/01/1992 - "Carbocyanines DiOC2(3) and DiSC2(3) did not correlate and were found to be 10 and 1000 times more potent than predicted, suggesting an additional factor at play in their phototoxicity."

Related Drugs and Biologics

1.	Carbocyanines
2.	Rhodamine 123
3.	Fluorescent Dyes (Fluorescent Probes)
4.	Ethidium (Ethidium Bromide)
5.	Coloring Agents (Dyes)
6.	Matrix Metalloproteinases (MMPs)

Related Therapies and Procedures

1.	Electrodes (Electrode)