Pradimicins and Benanomicins

Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.

Also Known As:

Pradimicin Like Polyketides; Pradimicin Type Polyphenols; Benanomicin Antibiotics; Benanomicin and Pradimicin Antibiotics; Benanomicinones; Benanomicins; Benanomicins and Pradimicins; Pradimicin Antibiotics; Pradimicin and Benanomicin Antibiotics; Pradimicin-Like Polyketides; Pradimicin-Type Polyphenols; Pradimicinones; Pradimicins

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Anthracyclines: 9423
        Pradimicins and Benanomicins: 4
- Lactones: 1549
  - Polyketides: 231
    - Pradimicins and Benanomicins: 4
- Quinones: 434
  - Naphthoquinones: 418
    - Pradimicins and Benanomicins: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Anthracyclines: 9423
      - Pradimicins and Benanomicins: 4
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Pradimicins and Benanomicins: 4
Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Anthracyclines: 9423
      - Pradimicins and Benanomicins: 4

1.	Infections 04/01/1993 - "Pradimicin T1 exhibited potent activity against a wide spectrum of fungi in vitro and demonstrated efficacy against systemic Candida albicans and Aspergillus fumigatus infections in mice."

pradimicin T1

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Bio-Agent Context: Research Results

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