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Checkpoint kinase 1

protein kinase that can bind to single-stranded DNA; involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present; Cil is a liver-specific isoform from rat; RefSeq NM_001274 (human); NM_007691 (mouse); NM_080400 (rat)
Also Known As:
CHEK1 protein, human; CHK1 checkpoint homolog (S. pombe) protein, human; CHK1 protein, Drosophila; CHK1 protein, human; Checkpoint kinase 1, Drosophila; Chek1 protein, mouse; Chek1 protein, rat; Chk1 protein, S pombe; Chk1 protein, Xenopus; Chk1 protein, mouse; Cil protein, rat; Rad27 protein, mouse; SPCC1259.13 protein, S pombe; checkpoint kinase 1 homolog (S. pombe) protein, Xenopus; checkpoint kinase 1 homolog (S. pombe) protein, mouse; checkpoint kinase 1 homolog (S. pombe) protein, rat; checkpoint kinase-1, C elegans; checkpoint-1 kinase; chk-1 protein, C elegans; chk1 kinase; chk1 protein kinase; grapes protein, Drosophila; grp protein, Drosophila; hChk1 (human); mChk1 (murine); xchk1
Networked: 124 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Morgan, Meredith A: 6 articles (03/2014 - 01/2009)
2. Karnitz, Larry M: 5 articles (10/2012 - 07/2005)
3. Schwartz, Gary K: 4 articles (09/2014 - 04/2007)
4. Parsels, Leslie A: 4 articles (08/2013 - 01/2009)
5. Lawrence, Theodore S: 4 articles (08/2013 - 01/2009)
6. Maybaum, Jonathan: 4 articles (08/2013 - 01/2009)
7. Parsels, Joshua D: 4 articles (08/2013 - 01/2009)
8. Kaufmann, Scott H: 4 articles (10/2012 - 07/2005)
9. Dai, Yun: 4 articles (08/2012 - 12/2006)
10. Grant, Steven: 4 articles (08/2012 - 12/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Ataxia Telangiectasia (Louis Bar Syndrome)
3. Lung Neoplasms (Lung Cancer)
4. Leukemia
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Phosphotransferases (Kinase)
2. 17-(allylamino)-17-demethoxygeldanamycin (17AAG)
3. DNA (Deoxyribonucleic Acid)
4. gemcitabine
5. Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6. Proteins (Proteins, Gene)
7. Cytarabine (Cytosar-U)
8. Cisplatin (Platino)
9. fms-Like Tyrosine Kinase 3
10. RNA (Ribonucleic Acid)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Therapeutics
4. Radiotherapy
5. Aftercare (After-Treatment)