|1.||Morgan, Meredith A: 6 articles (03/2014 - 01/2009)|
|2.||Karnitz, Larry M: 5 articles (10/2012 - 07/2005)|
|3.||Schwartz, Gary K: 4 articles (09/2014 - 04/2007)|
|4.||Parsels, Leslie A: 4 articles (08/2013 - 01/2009)|
|5.||Lawrence, Theodore S: 4 articles (08/2013 - 01/2009)|
|6.||Maybaum, Jonathan: 4 articles (08/2013 - 01/2009)|
|7.||Parsels, Joshua D: 4 articles (08/2013 - 01/2009)|
|8.||Kaufmann, Scott H: 4 articles (10/2012 - 07/2005)|
|9.||Dai, Yun: 4 articles (08/2012 - 12/2006)|
|10.||Grant, Steven: 4 articles (08/2012 - 12/2006)|
11/18/2010 - "Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents."
04/01/2014 - "LY2603618 is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC(50) = 7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. "
03/06/2015 - "Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential anti-tumor agents. "
12/01/2013 - "Overexpression of checkpoint kinase 1 (CHK1) is associated with poorer patient outcome and therapeutic resistance in multiple tumor models. "
07/01/2012 - "Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?"
|2.||Ataxia Telangiectasia (Louis Bar Syndrome)
04/01/2012 - "Previous studies have demonstrated that inhibition of the ataxia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cells can induce such a synthetic lethal outcome. "
11/01/2011 - "The aim of this study was to identify an inhibitor of the G(2) checkpoint including the ataxia-telangiectasia-mutated and Rad3-related checkpoint kinase 1 pathway that selectively suppresses the growth of p53-deficient cells. "
12/01/2014 - "CLASPIN is an essential mediator in the DNA replication checkpoint, responsible for ATR (ataxia telangiectasia and Rad3-related protein)-dependent activation of CHK1 (checkpoint kinase 1). "
04/01/2014 - "The ataxia telangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling pathway activated in response to replication stress and is essential for the intra-S checkpoint. "
07/12/2013 - "This phosphorylation of Cdc25C was regulated by activation of the ataxia telangiectasia and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) pathway. "
|3.||Lung Neoplasms (Lung Cancer)
09/01/2014 - "In this study, we investigated the molecular mechanisms underlying the antitumor activity of LY2603618, a potent and selective small molecule inhibitor of Chk1 protein kinase, in human lung cancer cells. "
01/01/2015 - "No defects in ATM, ATR or Chk1 kinase activation, or FANCD2 monoubiquitination were identified in the lung cancer cell lines examined, including Calu6, and major alterations in these pathways were not identified in the TCGA database. "
03/04/2011 - "Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy."
04/01/2013 - "Furthermore, mechanistic studies indicated that combined PARP inhibitor and cisplatin could lead to sustained DNA double-strand breaks, prolonged G2/M cell cycle arrest with distinct activation of checkpoint kinase 1 signaling and more pronounced apoptosis preferentially in lung cancer cells with low ERCC1 expression. "
04/01/2014 - "Treatment of Calu-6 human mutant TP53 lung cancer cell xenografts with gemcitabine resulted in a stimulation of Chk1 kinase activity that was inhibited by co-administration of LY2603618. "
11/01/2012 - "Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells."
05/01/2006 - "In addition, the expression and ATR-mediated phosphorylation of Chk1 kinase on serine 345 were often more abundant in BCR/ABL-positive leukemia cells than normal counterparts after genotoxic treatment. "
05/01/2006 - "Inhibition of ATR kinase by caffeine but not Chk1 kinase by indolocarbazole inhibitor, SB218078 sensitized BCR/ABL leukemia cells to MMC in a short-term survival assay. "
11/01/2011 - "In preclinical studies the heat shock protein 90 (Hsp90) inhibitor tanespimycin induced down-regulation of checkpoint kinase 1 (Chk1) and other client proteins as well as increased sensitivity of acute leukemia cells to cytarabine. "
03/01/2007 - "In this study, we evaluated the effects of etoposide and 17-AAG in leukemia cells and the roles of Hsp90, FMS-like tyrosine kinase 3 (FLT3), checkpoint kinase 1 (Chk1), Rad51, and topoisomerase II in this inhibition. "
|5.||Breast Neoplasms (Breast Cancer)
06/01/2014 - "Here, we identified Checkpoint kinase 1 (Chk1) as a potent therapeutic target in triple-negative breast cancer (TNBC). "
04/01/2013 - "Microcephalin 1 (MCPH1) has a crucial role in the DNA damage response by promoting the expression of checkpoint kinase 1 (CHK1) and breast cancer susceptibility gene 1 (BRCA1). "
09/01/2008 - "Microcephalin (MCPH1) has a crucial role in the DNA damage response by promoting the expression of Checkpoint kinase 1 (CHK1) and Breast cancer susceptibility gene 1 (BRCA1); however, the mechanism of this regulation remains unclear. "
01/01/2010 - "The genes differentially expressed in RB as compared to normal retina belong mainly to DNA damage-response pathways, including, but not limited to, breast cancer associated genes (BRCA1, BRCA2), ataxia telangiectasia mutated gene (ATM), ataxia telangiectasia and Rad3 related gene(ATR), E2F, checkpoint kinase 1 (CHK1) genes. "
08/01/2012 - "The present studies sought to define whether checkpoint kinase 1 (CHK1) inhibitors and poly(ADP-ribose) polymerase 1 (PARP1) inhibitors interact in vitro and in vivo to kill breast cancer cells. "
|3.||DNA (Deoxyribonucleic Acid)
|5.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|6.||Proteins (Proteins, Gene)
|9.||fms-Like Tyrosine Kinase 3
|10.||RNA (Ribonucleic Acid)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)