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SDZ 62-434
may be an inhibitor of signal transduction in cancer cells; structure given in first source; PAF antagonist
Also Known As:
SDZ-62-434; Imidazo(2,1-a)isoquinoline, 2,3-dihydro-5-(4-(1-piperidinylmethyl)phenyl)-, dihydrochloride
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
SDZ 62-434: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
SDZ 62-434: 4
Related Diseases
1.
Neoplasms (Cancer)
05/01/1993 - "
This suggests a possible role for SDZ 62-434 as an inhibitor of signal transduction in cancer cells.
"
01/01/1991 - "
SDZ 62-434, SDZ 62-759, SDZ 63-135, SDZ 63-596, and SDZ 62-293 have been further tested in a human tumor cloning assay in 5 cell lines.
"
05/01/1993 - "
The novel imidazoisoquinoline SDZ 62-434, originally identified as a platelet-activating factor (PAF) antagonist, has antiproliferative activity in a range of cell lines from human solid and haematological malignancies.
"
12/24/1992 - "
Four new antagonists of platelet activating factor (PAF) from two different chemical classes (imidazoisoquinolines: SDZ 62-434, SDZ 63-135, SDZ 62-759; imidazopiperidines: SDZ 62-293) were tested for in vivo therapeutic activity in various tumor models including the murine myelomonocytic leukemia WEHl-3B, xenografts of human colon (HTB 38) and lung (HTB 119) cancer cell lines and the murine Lewis-lung tumor.
"
01/20/1995 - "
5-[4'-(Piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1- a]isoquinoline (SDZ 62-434, 53) was more effective on a milligram per kilogram basis than the clinical cytostatic agent edelfosine (1) in increasing survivors and decreasing tumor volume in the oral mouse Meth A fibrosarcoma assay.
"
2.
Leukemia
12/24/1992 - "
Four new antagonists of platelet activating factor (PAF) from two different chemical classes (imidazoisoquinolines: SDZ 62-434, SDZ 63-135, SDZ 62-759; imidazopiperidines: SDZ 62-293) were tested for in vivo therapeutic activity in various tumor models including the murine myelomonocytic leukemia WEHl-3B, xenografts of human colon (HTB 38) and lung (HTB 119) cancer cell lines and the murine Lewis-lung tumor.
"
3.
Fibrosarcoma
01/20/1995 - "
5-[4'-(Piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1- a]isoquinoline (SDZ 62-434, 53) was more effective on a milligram per kilogram basis than the clinical cytostatic agent edelfosine (1) in increasing survivors and decreasing tumor volume in the oral mouse Meth A fibrosarcoma assay.
"
Related Drugs and Biologics
1.
Platelet Activating Factor
2.
Cytostatic Agents
3.
isoquinoline
4.
4-trifluoromethylsalicylic acid (HTB)
5.
edelfosine