Copper-Transporting ATPases

P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.

Also Known As:

ATP7A Protein; ATPase Copper Transporting alpha; Copper Pump 1; PINA Enzyme; Wilson Disease Protein; ATP7B Cu Binding P Type ATPase; ATPase 1, Copper-Transporting; ATPase 2, Copper-Transporting; ATPase, Copper-Transporting; ATPase, Pineal Night-Specific; ATPases, Copper-Transporting; ATPases, Cu-Transporting; Adenosine Triphosphatases, Copper-Transporting; Copper Transporting ATPase; Copper Transporting ATPase 1; Copper Transporting ATPase 2; Copper Transporting ATPases; Copper Transporting Adenosine Triphosphatases; Cu Transporting ATPases; Menkes Disease Associated Protein; Night-Specific ATPase, Pineal; Pineal Night Specific ATPase; Triphosphatases, Copper-Transporting Adenosine; Wilson Disease Cu Binding P Type ATPase; ATP7B Cu-Binding P Type ATPase; ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease); Copper-Transporting ATPase; Copper-Transporting ATPase 1; Copper-Transporting ATPase 2; Copper-Transporting Adenosine Triphosphatases; Cu(+)-Transporting ATPases; Cu-Transporting ATPases; Menkes Disease-Associated Protein; Pineal Night-Specific ATPase; Wilson Disease Cu-Binding P Type ATPase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        P-type ATPases: 226
        Copper-Transporting ATPases: 142
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - P-type ATPases: 226
        Copper-Transporting ATPases: 142
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Copper Transport Proteins: 197
        Copper-Transporting ATPases: 142
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - P-type ATPases: 226
        Copper-Transporting ATPases: 142
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Copper Transport Proteins: 197
        Copper-Transporting ATPases: 142

human ATP7A protein

Bio-Agent Context: Research Results