|1.||Fink-Puches, Regina: 1 article (12/2004)|
|2.||Helige, Christine: 1 article (12/2004)|
|3.||Hofmann-Wellenhof, Rainer: 1 article (12/2004)|
|4.||Smolle, Josef: 1 article (12/2004)|
|5.||Boiocchi, Mauro: 1 article (02/2003)|
|6.||De Rossi, Anita: 1 article (02/2003)|
|7.||Dolcetti, Riccardo: 1 article (02/2003)|
|8.||Righetti, Elisabetta: 1 article (02/2003)|
|9.||Cariati, Roberta: 1 article (02/2003)|
|10.||Zancai, Paola: 1 article (02/2003)|
12/01/1999 - "Arotinoid Ro 40-8757 caused marked decrease in the number and branching of mammary ducts, and inhibited mammary tumor development with significant decrease in the incidence, multiplicity, and tumor weights compared to the NTP-2000 diet control. "
04/01/1998 - "Arotinoid Ro-40-8757 at both doses inhibited the development of mammary tumors for the duration of the study. "
04/15/1994 - "In order to determine if Ro 40-8757 had a protective effect on 5-FU-treated animals, several studies were performed with non-tumor-bearing mice. "
10/01/2002 - "The results suggest that Ro 40-8757 inhibits the growth of human cancer cell lines in vitro by means of cell cycle arrest (mediated by up-regulating cell cycle protein P21 and P27) instead of cytotoxic effects, differentiation, or apoptosis."
10/01/2002 - "Ro 40-8757 significantly inhibited the growth of the four cancer cell lines in a dose-, time-dependent manner and without any signs of cytotoxicity, differentiation, or apoptosis. "
|3.||Melanoma (Melanoma, Malignant)
12/01/2004 - "In conclusion, our data demonstrate that mofarotene, an already almost forgotten synthetic retinoid, shows interesting effects on melanoma cells, which may be relevant for a slowdown of tumour spread."
12/01/2004 - "Although 10 microM mofarotene did not reduce the translocative movements of melanoma cells, it significantly inhibited stationary motility, including fast plasma membrane movements and changes in shape. "
12/01/2004 - "In this study, the effects of the arotinoid mofarotene on single cell motility and vinculin organization of the highly metastatic melanoma cell line K-1735-M2 were determined. "
12/01/2004 - "Mofarotene-induced inhibition of melanoma cell motility by increasing vinculin-containing focal contacts."
|4.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|5.||Breast Neoplasms (Breast Cancer)
09/30/1994 - "The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro."
09/30/1993 - "The arotinoid Ro 40-8757 is a novel compound that has significant therapeutic activity against chemically induced breast tumors in rats. "
09/15/1994 - "To understand the mechanism of action of the antitumor arotinoid mofarotene (Ro 40-8757), differential screening of cDNA libraries with cDNA probes prepared from treated or untreated breast-cancer cells was performed. "
05/15/1993 - "Comparison of the therapeutic effects of a new arotinoid, Ro 40-8757, and all-trans- and 13-cis-retinoic acids on rat breast cancer."
|3.||Cell Cycle Proteins
|5.||Etoposide (VP 16)
|9.||Complementary DNA (cDNA)