HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

W 77

structure given in first source; modulates adriamycin activity; also inhibits P-glycoprotein; calmodulin antagonist

Also Known As:

W-77; p-(2-aminoethyloxy)-N-(2-(4-benzyloxycarbonylpiperazinyl)-1-(p-methoxybenzyl)ethyl)-N-methylbenzenesulfonamide dihydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.

Carcinoma (Carcinomatosis)

05/01/1993 - "We also purified GST from Adriamycin-resistant cells and found that W-77 bound to the GST obtained from these ovarian carcinoma cells. "
05/01/1993 - "A newly synthesized bifunctional inhibitor, W-77, enhances adriamycin activity against human ovarian carcinoma cells."
05/01/1997 - "A newly synthesized drug, CKA1083 ((S)-N-[2-(4-benzyloxy-carbonylpiperazinyl)-1-(P-methoxybenzyl) ethyl]-N-methyl-N(5-isoquinolinesulfonamide)), has the same glutathione-S-transferase (GST)-binding site structure as W-77, a bifunctional inhibitor that enhances the cytotoxicity of Adriamycin for human ovarian carcinoma cells. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Glutathione Transferase (Glutathione S-Transferase)
3.	CKA1083