|1.||Ghosh, Jagadananda: 4 articles (08/2013 - 03/2004)|
|2.||Gravel, Sylvie: 2 articles (08/2015 - 06/2011)|
|3.||Rokach, Joshua: 2 articles (08/2015 - 06/2011)|
|4.||Powell, William S: 2 articles (08/2015 - 06/2011)|
|5.||Sarveswaran, Sivalokanathan: 2 articles (08/2013 - 12/2012)|
|6.||Reddy, Chintam Nagendra: 1 article (08/2015)|
|7.||Snyder, Nathaniel W: 1 article (08/2015)|
|8.||Mesaros, Clementina A: 1 article (08/2015)|
|9.||Gore, Vivek: 1 article (08/2015)|
|10.||Ye, Qiuji: 1 article (08/2015)|
|1.||Prostatic Neoplasms (Prostate Cancer)
08/09/2013 - "Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. "
12/01/2012 - "WDL does not affect the viability of normal prostate epithelial cells (PrEC) at doses that kill prostate cancer cells, and WDL-induced apoptosis is effectively prevented by 5-oxoETE, a metabolite of 5-Lox (but not by 15-oxoETE, a metabolite of 15-Lox), suggesting that the apoptosis-inducing effect of WDL in prostate cancer cells is mediated via inhibition of 5-Lox activity. "
01/06/2006 - "However, molecular mechanisms by which 5(S)-HETE and its derivative 5-oxoETE exert their effects on prostate cancer cell survival are yet to be understood. "
01/06/2006 - "Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival."
06/01/2011 - "The 5-lipoxygenase (5-LO) product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent chemoattractant for myeloid cells, is known to promote the survival of prostate cancer cells. "
06/01/2011 - "Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid."
10/01/2005 - "MDA-MB-231, MCF7, and SKOV3 cancer cells, but not HEK-293 cells, expressed mRNA for the leukocyte G protein-coupled 5-oxo-eicosatetraenoate (ETE) OXE receptor. "
|3.||Asthma (Bronchial Asthma)
08/01/2015 - "The 5-lipoxygenase product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is the most powerful human eosinophil chemoattractant among lipid mediators and could play a major pathophysiological role in eosinophilic diseases such as asthma. "
08/15/2001 - "5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), a metabolite of arachidonic acid formed by the 5-lipoxygenase pathway, is a potent eosinophil chemoattractant that may be an important mediator in asthma. "
|1.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|2.||GTP-Binding Proteins (G-Protein)
|3.||Phospholipase C beta
|4.||Small Interfering RNA (siRNA)
|5.||Arachidonic Acid (Vitamin F)
|7.||Messenger RNA (mRNA)
|9.||Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)
|10.||Arachidonate 12-Lipoxygenase (12 Lipoxygenase)