emt protein-tyrosine kinase (IL2-inducible T-cell kinase)

A non-receptor protein tyrosine kinase of the Tec family that participates in the intracellular signaling through antigen receptors such as the T-cell receptor, B-cell receptor, and Fc epsilon; amino acid sequence given in first source; isolated from murine mast cells; RefSeq NM_005546 (human), NM_010583 (mouse); do not confuse with TSK proteoglycan, mouse

Also Known As:

IL2-inducible T-cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase, human; IL2-inducible T-cell kinase, mouse; IL2-inducible T-cell kinase, rat; ITK protein, human; Itk protein, mouse; Itk protein, rat; Kinase EMT protein, human; Kinase EMT protein, mouse; LYK protein, human; T-cell-specific kinase; T-cell-specific kinase, human; Tcsk protein, mouse; Tsk protein, mouse; inducible T cell kinase; interleukin-2 tyrosine kinase

Networked: 38 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	August, Avery: 5 articles (01/2021 - 05/2003)
2.	Burch, Jason D: 3 articles (12/2016 - 07/2014)
3.	McEwan, Paul A: 3 articles (12/2016 - 07/2014)
4.	Ortwine, Daniel F: 3 articles (12/2016 - 07/2014)
5.	Pei, Zhonghua: 3 articles (12/2016 - 07/2014)
6.	Mohammad, Dara K: 2 articles (10/2018 - 03/2013)
7.	Nore, Beston F: 2 articles (10/2018 - 03/2013)
8.	Smith, C I Edvard: 2 articles (10/2018 - 03/2013)
9.	Schwartzberg, Pamela L: 2 articles (01/2017 - 03/2009)
10.	MacKinnon, Colin H: 2 articles (12/2016 - 07/2014)

Related Diseases

1.	Asthma (Bronchial Asthma) 05/01/2011 - "Asthma manifests as TH2-dominant airway inflammation regulated by inducible T-cell kinase (ITK). " 12/01/2016 - "Inhibition of inducible T-cell kinase (ITK), a nonreceptor tyrosine kinase, may represent a novel treatment for allergic asthma. " 05/01/2011 - "The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell Kinase gene with asthma." 05/15/2003 - "The Tec family nonreceptor tyrosine kinase inducible T cell kinase (ITK) has been shown to play a role in the differentiation and/or function of T(H)2-type cells, suggesting that ITK may represent a good target for the control of asthma. " 04/01/2006 - "We have previously shown that mice lacking the tyrosine kinase inducible T-cell kinase (ITK) have drastically reduced airway inflammation in a model of allergic asthma. "
2.	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 03/08/2013 - "The inducible T cell kinase-spleen tyrosine kinase (ITK-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and it is believed to be the cause of peripheral T cell lymphoma. " 10/12/2018 - "In this study, we characterized the role of ITK-FER [Interleukin-2-inducible T-cell Kinase (ITK) gene fused with Feline Encephalitis Virus-Related kinase (FER) gene] and ITK-SYK [Interleukin-2-inducible T-cell Kinase (ITK) gene fused with the Spleen Tyrosine Kinase (SYK)] in Peripheral T Cell Lymphoma (PTCL) signaling. "
3.	Neoplasms (Cancer) 06/27/2012 - "Interleukin-2, tyrosine kinase inhibitors and mammalian target of rapamycin inhibitors showed no effect on tumor progression. " 11/01/2019 - "Among the agents capable of killing cells cultured in both formats was a 1H-benzo[d]imidazol-2-amine-based inhibitor of IL2-inducible T-cell kinase (ITK; NCGC00188382, inhibitor #1) that effectively mediated growth inhibition and induction of apoptosis in vitro, and suppressed cancer progression and metastasis formation in vivo An examination of this agent's polypharmacology via in vitro and in situ phosphoproteomic profiling demonstrated an activity profile enriched for mediators involved in DNA damage repair. " 01/01/2023 - "We, therefore, investigated whether modulating chronic antigen stimulation and T-cell receptor (TCR) signaling with an IL2-inducible T-cell kinase (ITK) inhibitor, could confer ICB responsiveness to ICB resistant solid tumors. " 01/01/2023 - "IBR also irreversibly inhibits interleukin-2 inducible T cell kinase (ITK), an essential enzyme in Th2-polarized T cells that participates in tumor immunosuppression. " 01/01/2016 - "Ibrutinib, an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and IL2-inducible T-cell kinase (ITK), is in clinical use for the treatment of B-cell malignancies. "
4.	Inflammation (Inflammations) 10/01/2013 - "IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells." 05/01/2011 - "Asthma manifests as TH2-dominant airway inflammation regulated by inducible T-cell kinase (ITK). " 05/01/2014 - "Inhibition of IL-2 inducible T-cell kinase alleviates T-cell activation and murine myocardial inflammation associated with CVB3 infection." 04/01/2006 - "We have previously shown that mice lacking the tyrosine kinase inducible T-cell kinase (ITK) have drastically reduced airway inflammation in a model of allergic asthma. " 01/01/2004 - "It has been shown that the Tec family nonreceptor tyrosine kinase inducible T cell kinase (ITK) plays a role in the activation of naive T cells and in the differentiation of T helper (TH2)-type cells producing cytokines in a model of allergic inflammation, thereby possibly indirectly mediating hyperresponsivenes of airway smooth muscle tone. "
5.	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 04/01/2014 - "X-linked lymphoproliferative disease (XLP) and IL-2-inducible T cell kinase (ITK) deficiency are rare immunodeficiencies with a spectrum of clinical manifestations. " 03/01/2011 - "IL-2-inducible T-cell kinase deficiency underlies a new primary immune deficiency which may account for part of the spectrum of Epstein Barr virus related lymphoproliferative disorders which can be successfully corrected by bone marrow transplantation." 01/01/2012 - "IL-2-inducible T-cell kinase (ITK) deficiency is a rare inherited immunodeficiency disease characterized by homozygous mutations in the ITK gene and the inability to control Epstein-Barr virus (EBV) infection leading to EBV-associated lymphoproliferative disorders of B cell origin. " 01/01/2019 - "The family of EBV (Epstein Barr Virus)-sensitive primary immune deficiencies is one such group and in this paper we describe three families: two with X-linked lymphoproliferative disease type-1 (XLP-1) and one with deficiency of Interleukin-2 Inducible T-cell Kinase (ITK). " 06/01/2011 - "Here we review the clinical and biologic features of several PIDs associated with enhanced susceptibility to viral infections and cancer, including X-linked lymphoproliferative disease; IL-2-inducible T-cell kinase deficiency; epidermodysplasia verruciformis; warts, hypogammaglobulinemia, infections, and myelokathexis syndrome; autosomal recessive hyper-IgE syndrome; X-linked agammaglobulinemia; and common variable immunodeficiency. "

Related Drugs and Biologics

1.	Protein-Tyrosine Kinases (Tyrosine Kinase)
2.	Interleukin-2 (IL2)
3.	Phosphotransferases (Kinase)
4.	Syk Kinase
5.	ibrutinib
6.	Agammaglobulinaemia Tyrosine Kinase
7.	T-Cell Antigen Receptors (T-Cell Receptor)
8.	Cytokines
9.	Tyrosine (L-Tyrosine)
10.	TOR Serine-Threonine Kinases

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Cell Transplantation
3.	Therapeutics