|1.||Bieker, James J: 4 articles (08/2013 - 04/2006)|
|2.||Perkins, Andrew: 2 articles (08/2014 - 04/2006)|
|3.||Gilsanz, Florinda: 2 articles (01/2012 - 02/2009)|
|4.||Gallagher, Patrick G: 2 articles (12/2008 - 06/2006)|
|5.||Bodine, David M: 2 articles (12/2008 - 06/2006)|
|6.||Rogers, Heather: 1 article (08/2014)|
|7.||Noguchi, Constance Tom: 1 article (08/2014)|
|8.||Wang, Xunde: 1 article (08/2014)|
|9.||Yang, Yanqin: 1 article (08/2014)|
|10.||Raghavachari, Nalini: 1 article (08/2014)|
06/01/2006 - "Circulating erythroid cells from EKLF-deficient/(A)gamma-globin embryos exhibited hemolysis reminiscent of that seen in patients with severe erythrocyte membrane defects. "
03/01/2000 - "Despite efficient production of hybrid malpha(2)-hgamma(2) hemoglobin in the fetal livers of EKLF(-/-) animals, hemolysis was not corrected and survival was not prolonged. "
03/01/2000 - "Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos."
06/01/2006 - "gamma-Globin expression improved globin chain imbalance, but hemolysis was not improved and no live-born EKLF-deficient/(A)gamma-globin mice were obtained. "
|2.||beta-Thalassemia (Cooley's Anemia)
09/01/2004 - "A novel silent beta-thalassemia mutation in the distal CACCC box affects the binding and responsiveness to EKLF."
05/01/1996 - "Availability of human EKLF will enable initiation of studies to molecularly assess whether it is functionally compromised in those cases of beta-thalassemia that contain a normal beta-globin gene locus."
01/14/1994 - "Together these results demonstrate that EKLF displays a strong discriminatory ability among potential DNA target sites consistent with the beta-thalassemia data. "
01/14/1994 - "We have directly tested whether CAC site point mutations (including two of the beta-thalassemia mutants) affect EKLF transactivation and DNA binding function. "
01/14/1994 - "Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor."
|3.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
02/01/2009 - "The aim of this study was to evaluate the biological correlation and prognostic impact of Gata-1, Gata-2, EKLF, and c-MPL transcript level in a group of 41 acute myeloid leukemia (AML) patients. "
02/01/2009 - "Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia."
01/01/2012 - "Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)."
09/15/2011 - "Mutations in the human erythroid Krüppel-like factor (EKLF) can lead to either anemia or the benign InLu phenotype. "
08/24/2010 - "Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor."
12/01/2008 - "EKLF-deficient (Eklf(-/-)) mice die at day 14.5 of gestation from severe anemia. "
11/01/2007 - "At E10.5, Ey- and betah1-globin mRNA is greatly reduced in EKLF(-/-)KLF2(-/-), compared with EKLF(-/-) or KLF2(-/-) embryos, consistent with the observed anemia. "
06/01/2006 - "Mice deficient in the transcription factor erythroid Krüppel-like factor, KLF1 (EKLF) die approximately 14.5 days postcoitum of anemia, attributed to decreased expression of the beta-globin gene. "
|5.||Acute Erythroblastic Leukemia (Erythroleukemia)
03/16/2001 - "To identify essential domains required for EKLF transactivation function, we cotransfected a human erythroleukemia cell line (K562) with a locus control region gamma/Luc-beta/Cat reporter and an EKLF expression vector. "
08/01/2008 - "We show here, using inducible shRNA expression, that EKLF knockdown in mouse erythroleukemia (MEL) cells decreases erythrocytic and increases megakaryocytic as well as Fli-1 gene expression. "
04/17/2006 - "Herein, we determine that 26S proteasome inhibitors lead to an accumulation of EKLF protein in murine erythroleukemia (MEL) cells. "
10/26/1999 - "On transiently transfected templates, both the locus control region and the EKLF-binding site are important for their recruitment to the beta-globin promoter in mouse erythroleukemia cells. "
05/01/1993 - "We describe a novel erythroid cell-specific cDNA (EKLF [erythroid Krüppel-like factor]) isolated by enriching for genes expressed in a mouse erythroleukemia cell line but not expressed in a mouse monocyte-macrophage cell line. "
|3.||beta-Globins (beta Globin)
|4.||Transcription Factors (Transcription Factor)
|5.||erythroid Kruppel-like factor
|6.||Messenger RNA (mRNA)
|7.||DNA (Deoxyribonucleic Acid)
|9.||Carrier Proteins (Binding Protein)
|10.||GATA2 Transcription Factor