polymerized bovine hemoglobin

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22 relevant articles (1 outcomes, 3 trials/studies) found for this Bio-Agent

Description: an ultrapurified, polymerized bovine hemoglobin possibly useful as a blood substitute

Also Known As:

upbHb

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hamilton, Karyn L: 1 article (09/2008)
2.	Monnet, Eric: 1 article (09/2008)
3.	White, Molly: 1 article (09/2008)
4.	Jacobs, Robert: 1 article (09/2008)
5.	Hackett, Tim: 1 article (09/2008)
6.	Sullivan, Tim: 1 article (09/2008)
7.	Gotshall, Robert W: 1 article (09/2008)
8.	Irwin, David C: 1 article (09/2008)
9.	Tissotvanpatot, Martha C: 1 article (09/2008)
10.	TissotvanPatot, Martha C: 1 article (09/2008)

Related Diseases

1.	Hemorrhagic Shock 11/01/2001 - "We tested the hypothesis that the combination of polymerized bovine hemoglobin (PBHg) with hypertonic saline may be beneficial for the initial management of hemorrhagic shock in 22 mongrel dogs (15 +/- 1 kg) bled to a mean arterial pressure (MAP) of 40 mm Hg in 5 min and maintained at this level for 45 min (shed blood volume approximately 50 ml/kg). " 03/01/2009 - "Polymerized bovine hemoglobin can improve small-volume resuscitation from hemorrhagic shock in hamsters." 07/25/1996 - "Using intravital fluorescence microscopy and the dorsal skin fold chamber model of the awake Syrian golden hamster, the microcirculatory changes occurring in the thin striated skin muscle were quantitatively analyzed before and after administration of an ultrapurified polymerized bovine hemoglobin solution (U-PBHb) under the following experimental conditions: (1) Hypervolemic infusion of U-PBHb at approximately 10% of calculated blood volume, (2) isovolemic exchange transfusion with U-PBHBb by replacing approximately 50% of calculated blood volume and (3) severe hemorrhagic shock by acute bleeding of approximately 50% of calculated blood volume to a MAP of 35 +/- 5 mm Hg for 45 min followed by resuscitation with U-PBHb. " 03/01/2009 - "Systemic and microvascular hemodynamic responses to hemorrhagic shock volume resuscitation with hypertonic saline followed by infusion of polymerized bovine hemoglobin (PBH) at different concentrations were studied in the hamster window chamber model to determine the role of plasma oxygen-carrying capacity and vasoactivity during resuscitation. " Order ALL the reference details at left...
2.	Shock 01/01/1997 - "In this study we show that polymerized bovine hemoglobin (Biopure 2) restores both cardiovascular and renal functions in an endotoxin-induced shock model in rats. " 11/01/1992 - "Polymerized bovine hemoglobin (PBH) was compared with hydroxyethyl starch (HES) in a hypovolemic shock model. " 11/01/2006 - "Early resuscitation with polymerized bovine hemoglobin reverses acidosis, but not peripheral tissue oxygenation, in a severe hamster shock model." Order ALL the reference details at left...
3.	Ventricular Fibrillation 03/01/1997 - "DESIGN: Randomized, interventional study, using a clinically relevant model of ventricular fibrillation with a prolonged arrest time and cardiopulmonary resuscitation based on external chest compression and aortic occlusion with oxygenated ultrapurified polymerized bovine hemoglobin infusion. " 03/01/1997 - "Dose-response relationship between aortic infusions of polymerized bovine hemoglobin and return of circulation in a canine model of ventricular fibrillation and advanced cardiac life support." Order ALL the reference details at left...
4.	Body Weight (Weight, Body) 10/01/1994 - "In this study we have examined the effects of a novel haemoglobin-based oxygen carrier on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) after resuscitation from a volume-controlled haemorrhage of 30 min (3.0 ml/100 g body weight) with ultrapurified, polymerized, bovine haemoglobin (UPBHB). " Order ALL the reference details at left...
5.	Hemorrhage 07/25/1996 - "Using intravital fluorescence microscopy and the dorsal skin fold chamber model of the awake Syrian golden hamster, the microcirculatory changes occurring in the thin striated skin muscle were quantitatively analyzed before and after administration of an ultrapurified polymerized bovine hemoglobin solution (U-PBHb) under the following experimental conditions: (1) Hypervolemic infusion of U-PBHb at approximately 10% of calculated blood volume, (2) isovolemic exchange transfusion with U-PBHBb by replacing approximately 50% of calculated blood volume and (3) severe hemorrhagic shock by acute bleeding of approximately 50% of calculated blood volume to a MAP of 35 +/- 5 mm Hg for 45 min followed by resuscitation with U-PBHb. " 11/01/2006 - "Initial resuscitation (25% of estimated blood volume) with polymerized bovine hemoglobin (PBH) or 10% hydroxyethyl starch (HES) occurred in concert with an equivolumetric bleeding to simulate the early, prehospital setting (exchange transfusion). " 11/01/2003 - "Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage." 07/01/2001 - "Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Oxygen
2.	Glucose (Dextrose)
3.	Hetastarch (Pentastarch)
4.	carbogen
5.	Nitric Oxide (Nitrogen Monoxide)
6.	HBOC 201 (Hemopure)

Related Therapies and Procedures

1.	Resuscitation
2.	Cardiopulmonary Resuscitation (CPR)
3.	Advanced Cardiac Life Support (Life Support, Advanced Cardiac)
4.	Hemodilution
5.	Drug Therapy (Chemotherapy)

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