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polymerized bovine hemoglobin

an ultrapurified, polymerized bovine hemoglobin possibly useful as a blood substitute
Also Known As:
upbHb
Networked: 32 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Cabrales, Pedro: 3 articles (01/2020 - 03/2009)
2. Palmer, Andre F: 2 articles (01/2020 - 10/2015)
3. Intaglietta, Marcos: 2 articles (03/2009 - 11/2006)
4. Tsai, Amy G: 2 articles (03/2009 - 11/2006)
5. Knoll, H: 1 article (01/2021)
6. Meisel, T: 1 article (01/2021)
7. Meiser, A: 1 article (01/2021)
8. Schröder, M: 1 article (01/2021)
9. Volk, T: 1 article (01/2021)
10. Beeler, Bradley W: 1 article (01/2020)

Related Diseases

1. Hemorrhagic Shock
2. Shock
3. Hemorrhage
11/01/2006 - "Initial resuscitation (25% of estimated blood volume) with polymerized bovine hemoglobin (PBH) or 10% hydroxyethyl starch (HES) occurred in concert with an equivolumetric bleeding to simulate the early, prehospital setting (exchange transfusion). "
07/01/2001 - "Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep."
07/25/1996 - "Using intravital fluorescence microscopy and the dorsal skin fold chamber model of the awake Syrian golden hamster, the microcirculatory changes occurring in the thin striated skin muscle were quantitatively analyzed before and after administration of an ultrapurified polymerized bovine hemoglobin solution (U-PBHb) under the following experimental conditions: (1) Hypervolemic infusion of U-PBHb at approximately 10% of calculated blood volume, (2) isovolemic exchange transfusion with U-PBHBb by replacing approximately 50% of calculated blood volume and (3) severe hemorrhagic shock by acute bleeding of approximately 50% of calculated blood volume to a MAP of 35 +/- 5 mm Hg for 45 min followed by resuscitation with U-PBHb. "
11/01/2003 - "Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage."
05/01/2000 - "While clinical studies with human cross-linked hemoglobin (DCLHb) have been stopped last year because of the results of two clinical trials showing an increased mortality in patients with stroke and multiple injury shock being treated with DCLHb in comparison with saline, a phase III study with polymerized bovine hemoglobin HBOC-201 is actually being performed in noncardiac patients with perioperative bleeding. "
4. Hypoxia (Hypoxemia)
5. Stroke (Strokes)

Related Drugs and Biologics

1. Oxygen (Dioxygen)
2. Hemoglobins (Hemoglobin)
3. HBOC 201 (Hemopure)
4. Glucose (Dextrose)
5. Endotoxins
6. diaspirin-cross-linked hemoglobin
7. Solutions
8. Starch (Cornstarch)
9. carbogen
10. Nitric Oxide (Nitrogen Monoxide)

Related Therapies and Procedures

1. Resuscitation
2. Cardiopulmonary Resuscitation (CPR)
3. Transplantation
4. Intravenous Administration
5. Advanced Cardiac Life Support (Life Support, Advanced Cardiac)