|1.||Cragg, Mark S: 1 article (01/2015)|
|2.||Lee, Chern Siang: 1 article (01/2015)|
|3.||Ghielmini, Michele: 1 article (01/2015)|
|4.||Rondeau, Stephanie: 1 article (01/2015)|
|5.||Cogliatti, Sergio: 1 article (01/2015)|
|6.||Schmitz, Shu-Fang Hsu: 1 article (01/2015)|
|7.||Johnson, Peter: 1 article (01/2015)|
|8.||Ashton-Key, Margaret: 1 article (01/2015)|
|9.||Yang, Qingyuan: 1 article (12/2012)|
|10.||Duan, Erzhen: 1 article (12/2012)|
07/01/1996 - "When stably transfected in the lymphoma B cells IIA1.6, or in the mast cells RBL-2H3, this cDNA encoded 32-kDa Fc gamma RIIB whose biologic properties were undistinguishable from those of Fc gamma RIIB1: they inhibited B cell activation when coaggregated to B cell receptors and capped when aggregated at 37 degrees C, but failed to mediate endocytosis or phagocytosis. "
02/16/1998 - "B lymphoma cells expressing recombinant FcgammaRIIb2 or FcgammaRIII were used to assess the presentation of several epitopes from two different antigens. "
11/20/2001 - "To study the molecular mechanism for negative regulation of lymphocytes through the PD-1 receptor, we generated chimeric molecules composed of the IgG Fc receptor type IIB (Fc gamma RIIB) extracellular region and the PD-1 cytoplasmic region and expressed them in a B lymphoma cell line, IIA1.6. Coligation of the cytoplasmic region of PD-1 with the B cell receptor (BCR) in IIA1.6 transformants inhibited BCR-mediated growth retardation, Ca(2+) mobilization, and tyrosine phosphorylation of effector molecules, including Ig beta, Syk, phospholipase C-gamma 2 (PLC gamma 2), and ERK1/2, whereas phosphorylation of Lyn and Dok was not affected. "
|2.||Melanoma (Melanoma, Malignant)
12/15/2008 - "We previously reported in a limited study that some human metastatic melanoma cells ectopically express the FcgammaRIIB1, an inhibitory isoform of FcgammaR. "
06/01/2005 - "To assess the contribution of MV-N domains and of these two receptors in suppression of cell proliferation, a human melanoma HT144 cell line expressing (HT144IIB1) or lacking FcgammaRIIB1 was used as a model. "
|4.||Autoimmune Diseases (Autoimmune Disease)
05/01/2012 - "Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. "
08/01/2000 - "Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis."
07/01/2002 - "Androgen-dependent expression of FcgammaRIIB2 by thyrocytes from patients with autoimmune Graves' disease: a possible molecular clue for sex dependence of autoimmune disease."
01/01/2002 - "These recent findings in animal models open the intriguing possibility that the human homologues of genes encoding the inhibitory receptors like Fc gamma RIIB or effector phosphatases like SHIP might contribute to autoimmune diseases. "
05/01/2000 - "Strains (group II) that per se are not autoimmune-prone, but have potentials to accelerate autoimmune diseases share two deletion sites in the third intron: one identical to that in group I and the other unique to group II. These polymorphisms correlated well with extents of down-regulation of FcgammaRIIB1 expression in germinal-center B cells upon stimulation with antigens and up-regulation of IgG antibody responses. "
02/01/2002 - "Microbiological analysis of genital chlamydial infection in FcR knockout (FcRKO) mice lacking the activatory FcgammaRI (CD64) and FcRgammaIII (CD16), as well as the inhibitory FcgammaRIIB1 (CD32), revealed a greater intensity of secondary infection (i.e. "
12/07/2012 - "Ligation of Fc gamma receptor IIB enhances levels of antiviral cytokine in response to PRRSV infection in vitro."
07/26/2011 - "Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection."
06/15/2002 - "Injection of CRP protected wild-type, FcR gamma-chain-, Fc gamma RIIb-, and Fc gamma RIII-deficient mice from infection. "
|1.||Fc Receptors (Fc Receptor)
|2.||Immunoglobulin G (IgG)
|3.||Phospholipase C gamma
|5.||IgG Receptors (Fc gamma RI)
|7.||Complementary DNA (cDNA)
|9.||DNA (Deoxyribonucleic Acid)