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1- (5- isoquinolinylsulfonyl)- 3- methylpiperazine

a positional isomer of H-7; inhibits protein kinase and cAMP-dependent protein kinase

Also Known As:

1-(5-isoquinolinesulfonyl)-3-methylpiperazine; iso-H-7; iso-H7

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: 277
        1-(5-isoquinolinylsulfonyl)-3-methylpiperazine: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: 277
      - 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: 277
        1-(5-isoquinolinylsulfonyl)-3-methylpiperazine: 1

Experts

1.	Li, Mei-Hua: 1 article (06/2004)
2.	Yang, Zhan-Quan: 1 article (06/2004)
3.	Yin, Wan-Zhong: 1 article (06/2004)

Related Diseases

1.

Nasal Polyps (Nasal Polyp)

06/01/2004 - "The nasal polyp tissues were cultured in Iso-H7 in concentration of 10(-6), 10(-4), 10(-2) mol/L for 1 d, 3 d, and 5 d, respectively. "
06/01/2004 - "Nasal polyp tissues were cultured and divided into two groups, test group (with Iso-H7 in different concentration) and control group (without the inhibitor of PKC), to check out the influence of Iso-H7 on eosinophil apoptosis in nasal polyps. "
06/01/2004 - "To study the influence of the inhibitor of protein kinase C (PKC), Iso-H7 [1-(5-lsoquinolinyl-sulfony)-3-methylpiperazine dihydrochloride] on eosinophil apoptosis in nasal polyp tissues. "

Related Drugs and Biologics

1.	Protein Kinase C