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trefentanil
RN refers to hydrochloride; a short-acting analgesic
Also Known As:
A 3665; A-3665
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Tetrazoles: 14
trefentanil: 1
Piperidines: 17
trefentanil: 1
Related Diseases
1.
Respiratory Insufficiency (Respiratory Failure)
04/01/1993 - "
At the 32 micrograms/kg and 64 micrograms/kg dose levels, five subjects each were to be enrolled (four to receive A-3665 and one to receive placebo); however, the study was terminated after two subjects in the 64 micrograms/kg group had significant respiratory depression.
"
04/01/1993 - "
A-3665 caused significant respiratory depression at doses of 32 micrograms/kg and 64 micrograms/kg, but alfentanil did not induce significant respiratory depression at the doses tested.(ABSTRACT TRUNCATED AT 250 WORDS)
"
2.
Pain (Aches)
04/01/1993 - "
There was no significant difference in analgesic potency of A-3665 and alfentanil as measured by tolerance to tibial pressure at 3 min. At the dose of 16 micrograms/kg, both drugs significantly increased pain tolerance to tibial pressure compared with placebo at 3 min, but alfentanil continued to display significant analgesic effect versus placebo and versus A-3665 at 6, 11, and 15 min after injection.
"
Related Drugs and Biologics
1.
Alfentanil (Alfenta)
2.
Analgesics (Analgesic Drugs)