1,1-dimethyl-4-acetylpiperazinium

01/01/2022 - "Clinical data indicate that elevated levels of HPIP and HIF-1α correlate with unfavorable prognosis and shorter survival rates in breast cancer subjects. "
01/01/2022 - "A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells."
10/10/2021 - "Acute metabolic stress induced proto-oncogene HPIP expression in an AMPK-FOXO3a-dependent manner in breast cancer (BC) cells. "
08/27/2015 - "Interestingly, HPIP is also proteolysed by calpain2 in breast cancer cells. "
08/27/2015 - "We show here that HPIP expression is associated with stages of breast cancer where cell dissemination results in poor patient outcome. "

05/01/2016 - "In conclusion, our findings identified HPIP plays an important role in the progression and EMT of spinal glioblastoma, by which cell growth is improved. "
05/01/2016 - "However, the molecular mechanisms underlying HPIP-induced epithelial-mesenchymal transition (EMT) in the spinal glioblastoma have been under investigation. "
05/01/2016 - "Here, in vitro assays revealed that HPIP mRNA and protein were highly expressed in five cases of spinal glioblastoma tissues, compared with non-tumor tissues. "

02/01/2017 - "Thus, in the present study, we investigated the role of HPIP in transforming growth factor (TGF)-β1-induced EMT in A549 lung cancer cells in vitro. "
01/01/2016 - "Previous studies showed that HPIP is frequently overexpressed in many tumors. "
01/01/2023 - "These results provide insights into EGFR-RAS-ERK signaling complex formation and EGFR-RAS-ERK signaling regulation and suggest that HPIP may be a promising therapeutic target for cancer with dysregulated EGFR-RAS-ERK signaling."
01/01/2023 - "Experiments of HPIP knockout or knockdown and chemical inhibition of HPIP expression showed that HPIP is required for EGFR-RAS-ERK signaling complex formation, EGFR-RAS-ERK signaling activation, and EGFR-RAS-ERK signaling-mediated promotion of aerobic glycolysis as well as cancer cell growth in vitro and in vivo. "
01/01/2021 - "Over the past 20 years, we have witnessed the emerging role of HPIP and its association with a myriad of cellular activities ranging from germ cell proliferation to cancer aggressiveness, modulating multitude of signaling cascades like TGF-β1, PI3K/AKT, Wnt, mTOR, and Sonic hedgehog signaling pathways. "

09/19/2017 - "The purpose of this study was to investigate the clinical significance of HPIP expression and the prognosis of patients with cervical cancer. "
01/01/2017 - "The aim of this study was to explore the relationships of HPIP expression status with the clinicopathological variables and survival outcomes of patients with cervical cancer (CC). "
09/19/2017 - "Moreover, results revealed that HPIP expression was an independently prognostic factor for both overall survival [hazard ratio (HR): 8.874; 95% CI: 1.186-66.393; P=0.033] and disease-free survival [(HR): 11.523; 95% CI: 1.531-86.746; P=0.018] in patients with cervical cancer. "
09/19/2017 - "Correlations of HPIP expression with clinicopathological factors and prognosis of patients with cervical cancer were analyzed. "
09/19/2017 - "Fresh frozen tissues from 10 samples of cervical cancer and 8normal cervical tissues were analyzed for HPIP expression using real-time reverse transcription PCR and Western blot analysis. "

09/01/2018 - "This study investigated the correlations of HPIP expression with clinicopathological factors and prognosis of cervical carcinoma patients. "
04/01/2017 - "OAW42, an ovarian carcinoma-derived cell line exhibiting a high HPIP expression, was used to study the role of HPIP in cell migration, invasion and EMT. "
10/01/2015 - "Increasing evidence suggests that HPIP is an oncogene which is frequently overexpressed in many human carcinomas. "