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rat Map3k8 protein

Tpl-2 is the rat homolog of human cot; a MAP3K kinase involved in the progression of rodent T-cell lymphomas & in T-cell activation; it up-regulates COX-2 gene expression in Jurkat T cells; It binds and induces NF-B-dependent transcription; RefSeq NM_053847
Also Known As:
Map3k8 protein, rat; Tpl2 protein, rat; cancer osaka thyroid kinase, rat; mitogen-activated protein kinase kinase kinase 8, rat; tumor progression locus 2 protein, rat
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Bio-Agent Context: Research Results