transcription factor nuclear factor 1

modulates liver-specific transcription by interactions with hepatocyte nuclear factor 3 & the eH site which is a segment of the liver-specific enhancer of the serum albumin gene; amino acid sequence has been determined

Also Known As:

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ali, Ekram: 1 article (01/2016)
2.	El Gazzar, Mohamed: 1 article (01/2016)
3.	McCall, Charles E: 1 article (01/2016)
4.	McClure, Clara: 1 article (01/2016)
5.	Yao, Zhi Q: 1 article (01/2016)
6.	Youssef, Dima: 1 article (01/2016)
7.	Hammond, G L: 1 article (04/2000)
8.	Ip, Y C: 1 article (04/2000)
9.	Lee, W M: 1 article (04/2000)

Related Diseases

1.	Hepatoblastoma 04/01/2000 - "However, the predominant footprint on the rbshbg promoter is conserved at the same position within the human shbg (hshbg) promoter and includes consensus binding sites for the transcription factor nuclear factor- 1. Transient transfection studies of the rbshbg 5'-flanking sequence (893 bp) revealed regions that actively enhance and repress its activity in human hepatoblastoma and mouse Sertoli cells, but not in Chinese hamster ovary cells. "
2.	Sepsis (Septicemia) 01/01/2016 - "Here, we show that during sepsis-induced generation of myeloid-derived suppressor cells, transcription factor nuclear factor 1 A type represses cyclin-dependent kinase inhibitor p21 to arrest differentiation of Gr1(+) CD11b(+) cells. "
3.	Avitaminosis (Vitamin Deficiency) 10/05/1993 - "However, modulation of hormone-induced gene expression was restored with the inclusion of a binding site for the transcription factor nuclear factor 1 (NF1) within the hormone-responsive promoter; glucocorticoid-induced gene expression was reduced by 44% under conditions of elevated intracellular vitamin B6 concentration and enhanced by 98% in mild vitamin deficiency. "

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase Inhibitor p21
2.	Vitamin B 6
3.	Hormones (Hormone)
4.	Glucocorticoids