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2,4- (alpha,beta- dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester

structure given in first source; used in neutron capture therapy; selectively localizes in rat 9L gliosarcoma

Also Known As:

2,4-bis(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester; BOPP cpd; Mn-BOPP

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Boron Compounds: 91
  - 2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1
Organic Chemicals: 133
- Boron Compounds: 91
  - 2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Tetrapyrroles: 70
        Porphyrins: 3316
        Deuteroporphyrins
        2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Tetrapyrroles: 70
      - Porphyrins: 3316
        Deuteroporphyrins
        2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Tetrapyrroles: 70
    - Porphyrins: 3316
      - Deuteroporphyrins
        2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1
Biological Factors: 2472
- Biological Pigments: 1
  - Porphyrins: 3316
    - Deuteroporphyrins
      - 2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester: 1

Related Diseases

1.	Neoplasms (Cancer) 03/01/1993 - "Mn-BOPP is unique in that it represents, to the authors' knowledge, the first example of a single agent that can enhance contrast between tumor and normal tissue and be potentially effective as an agent for boron neutron capture therapy." 03/01/1993 - "The results also indicate that Mn-BOPP may have a slower uptake in the 9L glioma than Mn-TPPS4 but a longer retention in the tumor. "
2.	Glioma (Gliomas) 03/01/1993 - "The results also indicate that Mn-BOPP may have a slower uptake in the 9L glioma than Mn-TPPS4 but a longer retention in the tumor. "

Related Drugs and Biologics

1.	manganese(III)tetraphenylporphine sulfonate

Related Therapies and Procedures

1.	Boron Neutron Capture Therapy