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liensinine

RN given for (R-(R*,R*))-isomer

Networked: 32 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - liensinine: 32
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        liensinine: 32

Experts

1.	Chen, Chang-Lan: 1 article (10/2022)
2.	Gou, Jiang-Min: 1 article (10/2022)
3.	Liu, Hong-Sheng: 1 article (10/2022)
4.	Liu, Song-Yao: 1 article (10/2022)
5.	Meng, Xue-Lian: 1 article (10/2022)
6.	Wang, Dan: 1 article (10/2022)
7.	Xu, Cheng-Bin: 1 article (10/2022)
8.	Xue, Jing-Su: 1 article (10/2022)
9.	Jiang, Ruilai: 1 article (03/2022)
10.	Liang, Liping: 1 article (03/2022)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 10/01/2022 - "PRACTICAL APPLICATIONS: This study highlighted the protective effects and mechanisms of three main active ingredients (Liensinine, Isoliensinine, and Neferine) in the lotus embryo on a typical cell model of Alzheimer's disease (AD). " 10/27/2023 - "Altogether, our findings provided a certain working foundation for the use of liensinine and neferine to treat Alzheimer's disease based on neuroprotective effects." 10/27/2023 - "It was reported that liensinine and neferine could inhibit the activities of acetylcholinesterase and cross the blood-brain barriers, suggesting their therapeutic potential for the management of Alzheimer's disease. "
2.	Reperfusion Injury 04/28/2023 - "The current study aimed to explore the role of autophagy in cerebral ischemia-reperfusion injuries (CIRI) and elucidate the efficacy of liensinine treatment. "
3.	Brain Ischemia (Cerebral Ischemia) 04/28/2023 - "The current study aimed to explore the role of autophagy in cerebral ischemia-reperfusion injuries (CIRI) and elucidate the efficacy of liensinine treatment. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "We further investigated the effects of autophagy inhibition by liensinine on the therapeutic efficacy of chemotherapeutic drugs and found that cotreatment of liensinine markedly decreased the viability and increased apoptosis in breast cancer cells treated with various chemotherapeutic agents. " 01/01/2015 - "Our findings suggest that liensinine could potentially be further developed as a novel autophagy/mitophagy inhibitor, and a combination of liensinine with classical chemotherapeutic drugs could represent a novel therapeutic strategy for treatment of breast cancer. " 01/01/2015 - "A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission." 01/01/2017 - "Liensinine also displayed significant inhibition on the migration and invasion of both MDA-MB-231 and MCF-7 human breast cancer cells compared with nuciferine. " 01/01/2017 - "Liensinine and nuciferine inhibited the growth of MDA-MB-231 and MCF-7 human breast cancer cells by inducing apoptosis and inhibiting proliferation via cell cycle arrest. "
5.	Ischemia 04/28/2023 - "Liensinine ameliorates ischemia-reperfusion-induced brain injury by inhibiting autophagy via PI3K/AKT signaling." 04/28/2023 - "An in vitro ischemia-reperfusion (I/R) neuronal cell model was established and pretreated with liensinine or rapamycin (RAPA). "

Related Drugs and Biologics

1.	neferine
2.	isoliensinine
3.	Alkaloids
4.	Benzylisoquinolines
5.	Biomarkers (Surrogate Marker)
6.	Proteins (Proteins, Gene)
7.	Lipopolysaccharides
8.	Doxorubicin (Adriamycin)
9.	dauricine
10.	nuciferine

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration