taraxasterol

07/25/2023 - "Our previous studies have demonstrated that taraxasterol exerts protective effects on alcoholic and immune liver injuries. "
01/01/2023 - "Our previous studies have shown that taraxasterol isolated from the traditional Chinese medicinal herb Taraxacum has protective effects against immune-mediated and alcoholic-induced liver injuries. "

06/01/2019 - "Our findings demonstrated that taraxasterol improved DSS-induced AEC through regulating MMP3 and PPARG expression, providing a new insight into the potential therapeutic strategies for acute colitis."
06/01/2019 - "However, the molecular mechanisms by which taraxasterol attenuates acute experimental colitis (AEC) remain undocumented. "
06/01/2019 - "Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis."
06/01/2019 - "14 collective targets of taraxasterol and acute colitis were identified by a network pharmacology analysis, including PPARG, JAK2, MMP3, NR1I2 and PTPN11. "
06/01/2019 - "A network pharmacology approach was used to identify the candidate and collective targets of taraxasterol and acute colitis, and an AEC model was established by oral administration of dextran sulfate sodium (DSS) in mice. "

10/01/2018 - "In the present study, we used the human umbilical vein endothelial cells (HUVECs) to investigate the anti-inflammatory effects and mechanism of taraxasterol on vascular inflammation. "
12/01/2020 - "In conclusion, these findings indicate that taraxasterol has a protective effect on IRI-induced AKI via inhibition of oxidative stress, inflammation, and apoptosis."
10/01/2018 - "Here, we found that taraxasterol inhibited vascular inflammation through activating LXRα."
04/01/2014 - "The aims of this study were to investigate whether taraxasterol could ameliorate the inflammation response in LPS-induced acute lung injury and to clarify the possible mechanism. "
09/01/2019 - "Therefore, taraxasterol may be a promising agent for decreasing the inflammatory response in ulcerative colitis and other inflammation-related diseases."

10/15/2016 - "This study aimed to investigate the protective effects and mechanism of taraxasterol on CS-induced lung inflammation in mice. "
10/15/2016 - "In conclusion, our results suggested that taraxasterol had protective effects of CS-induced lung inflammation. "
10/15/2016 - "CS-induced mouse lung inflammation model was used to investigate the protective effects of taraxasterol in vivo. "
10/15/2016 - "However, the protective effects of taraxasterol against cigarette smoke (CS)-induced lung inflammation have not been reported. "
10/15/2016 - "Taraxasterol inhibits cigarette smoke-induced lung inflammation by inhibiting reactive oxygen species-induced TLR4 trafficking to lipid rafts."

03/25/2022 - "Taraxasterol ameliorates dextran sodium sulfate-induced murine colitis via improving intestinal barrier and modulating gut microbiota dysbiosis."