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BIBN 99

structure given in first source; a highly selective M2 antagonist

Also Known As:

BIBN-99

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - BIBN 99: 4
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzazepines: 4
      - BIBN 99: 4

Related Diseases

1.	Bradycardia 09/21/1993 - "In vivo studies revealed that BIBN 99 is able to cross the blood-brain barrier, and although showing an approximately 3-fold higher affinity for M2 binding sites BIBN 99 appeared to be 7- to 18-fold less potent than AF-DX 116 in inhibiting muscarinic agonist or vagally induced bradycardia in rats and guinea-pigs. "
2.	Cognitive Dysfunction 01/01/1993 - "The prototype of this novel class of M2 selective compounds, BIBN 99, could be a valuable tool to test the hypothesis that lipophilic M2 antagonists show beneficial effects in the treatment of cognitive disorders."
3.	Amnesia (Dissociative Amnesia) 02/01/1995 - "Similarly, BIBN-99 reversed scopolamine-induced amnesia in young animals. "
4.	Traumatic Brain Injuries (Traumatic Brain Injury) 07/17/1995 - "Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats."

Related Drugs and Biologics

1.	Muscarinic Agonists
2.	otenzepad
3.	Muscarinic M2 Receptor
4.	Scopolamine (Hyoscine)