U 88999E

inhibits lipid peroxidation & acts as a calcium antagonist; may be useful in the prevention of cerebral vasospasms after subarachnoid hemorrhage

Also Known As:

7-(4-(4,4'-difluorobenzhydryl)piperazino-1-methyl)-4-isopropyl-2-methoxy-2,4,6-cycloheptatrien-1-one hydrochloride; U-88999E; U88999E

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Intracranial Vasospasm 02/01/1993 - "The effects of U88999E on basilar artery tone were examined in two model systems: 1) an in vitro preparation of arterial rings that measures isometric tension, and 2) an in vivo model of cerebral vasospasm measuring arterial diameter. " 02/01/1993 - "Effect of U88999E on experimental cerebral vasospasm in rabbits." 02/01/1993 - "These findings suggest that U88999E may be useful in the prevention of cerebral vasospasm after subarachnoid hemorrhage."
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 02/01/1993 - "Vasospasm of basilar arteries after subarachnoid hemorrhage was inhibited in a dose-dependent and significant manner by intravenous injections of U88999E. " 02/01/1993 - "These findings suggest that U88999E may be useful in the prevention of cerebral vasospasm after subarachnoid hemorrhage."

1.	Intravenous Injections