cefoselis

structure given in first source

Also Known As:

FK 037; FK-037; FK037; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-, sulfate (salt) (1:1)

Networked: 20 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bai, J-L: 1 article (01/2014)
2.	Guo, D-Y: 1 article (01/2014)
3.	He, P: 1 article (01/2014)
4.	Jiang, N: 1 article (01/2014)
5.	Li, X-S: 1 article (01/2014)
6.	Lin, J-M: 1 article (01/2014)
7.	Liu, Y-B: 1 article (01/2014)
8.	Liu, Y-J: 1 article (01/2014)
9.	Lv, X-J: 1 article (01/2014)
10.	Qiu, H-M: 1 article (01/2014)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2014 - "Cefoselis is an effective and safe choice against acute moderate and severe respiratory infections and UTI (urinary tract infection)." 01/01/2014 - "A total of 276 patients (138 with Cefoselis, 138 with Cefepime) with respiratory or urinary tract infections were enrolled in the study. "
2.	Infections 11/01/2000 - "Clinical effects of cefoselis (CFSL) on various infections and prevention of postoperative infections in the field of obstetrics and gynecology were investigated with a total of 100 patients of 8 facilities in Yamagata and the following results were obtained: 1. For the patients (n = 70) who received the treatment with CFSL at 2 g/day for 5 days to prevent postoperative infections, the treatment was effective for such infections in 68 of 69 (98.6%) except one to whom the treatment was discontinued during the course. " 11/01/2000 - "[Clinical effects of cefoselis (CFSL) on infections in obstetric and gynecologic field and prevention of postoperative infections]." 10/01/1994 - "Our results indicate that FK-037 should prove to be efficacious in the treatment of a wide range of systemic infections." 05/01/1994 - "FK037 had a potent protective activity against murine experimental systemic infections due to a wide variety of bacteria. " 02/01/1993 - "In murine systemic infection models, FK037 showed potent activity against P. "
3.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/2014 - "Cefoselis is an effective and safe choice against acute moderate and severe respiratory infections and UTI (urinary tract infection)."
4.	Prostatitis 12/01/1994 - "We conclude that FK037 is highly effective in the treatment of acute bacterial prostatitis, and is well tolerated in comparison with other relative antimicrobials." 12/01/1994 - "[Clinical study of a new injectable cephem, FK037, for acute bacterial prostatitis]." 12/01/1994 - "FK037, a new injectable cephem antibiotic, was administered in the treatment of 13 acute bacterial prostatitis (mean age 53.5, range 30-79), and its effectiveness and safety were evaluated. "
5.	Renal Insufficiency (Renal Failure) 12/01/2004 - "In this study, we examined the BBB penetration of cefoselis in normal and renal failure rats by means of brain microdialysis. " 12/01/2004 - "However, the additional factor, such as decrease in brain function related to aging, would be involved in seizures in patient received cefoselis, because an extremely high dose was required to induce seizures even in renal failure rats. " 09/01/2001 - "We investigated the effect of infusion rate and experimental renal failure on the pharmacodynamics of cefoselis (CFSL)-induced seizures. " 09/01/2001 - "Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats." 12/01/2004 - "However, a systematic cefoselis administration via the tail vein did not elevate extracellular glutamate and GABA concentrations in the hippocampus of renal failure rats that exhibited marked seizures. "

Related Drugs and Biologics

1.	Cephalosporins (Cephalosporin Antibiotics)
2.	Cefepime (Maxipime)
3.	Cantharidin (Cantharides)
4.	Ceftazidime (Fortum)
5.	Cefpirome (HR 810)
6.	Imipenem
7.	Anti-Bacterial Agents (Antibiotics)
8.	Therapeutic Uses
9.	Methicillin (Metin)
10.	Aztreonam

Related Therapies and Procedures

1.	Injections