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HTLV-1 protease (PR14)

has been sequenced

Also Known As:

PR14; HTLV-1 proteinase; human T-cell leukemia virus type 1 protease

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Aspartic Acid Endopeptidases: 2
        HTLV-1 protease: 5
      - Aspartic Acid Proteases: 410
        Aspartic Acid Endopeptidases: 2
        HTLV-1 protease: 5

Experts

1.	Al-Shammari, Abdullah A: 1 article (01/2021)
2.	Ali, Akbar: 1 article (01/2021)
3.	Doody, Natalie E: 1 article (01/2021)
4.	Egginton, Stuart: 1 article (01/2021)
5.	Henes, Mina: 1 article (01/2021)
6.	Kissane, Roger W P: 1 article (01/2021)
7.	Kosovrasti, Klajdi: 1 article (01/2021)
8.	Kurt Yilmaz, Nese: 1 article (01/2021)
9.	Lockbaum, Gordon J: 1 article (01/2021)
10.	Mansky, Louis M: 1 article (01/2021)

Related Diseases

1.	Fatigue 01/01/2021 - "Compared to controls, capillary-to-fiber ratio was higher after OV14 (134%, p < .001) and PR14 (121%, p < .05), although fatigue resistance only improved after overload (7 days: 135%, 14 days: 125%, p < .05). "
2.	Neoplasms (Cancer) 09/15/2007 - "Our in vivo studies using Pr14 cells xenografted into nude mice demonstrated that MSA significantly enhances the chemotherapeutical effect of etoposide, resulting in 78.3% tumor growth inhibition. " 09/15/2007 - "We have investigated the effect of methylseleninic acid (MSA) on tumor stage-specific prostate cells derived from the C3 (1)/Tag model for PrCa: Pr111, a slow-growing and nontumorigenic cell line isolated from a prostate intraepithelial neoplasia lesion; Pr14, a tumorigenic line derived from a primary tumor; and Pr14C1, a sub-clone of Pr14 explanted from a lung metastasis. " 09/15/2007 - "The expression of neuropilin-1, a protein involved in VEGF signaling and tumor angiogenesis, was 97-fold repressed in Pr14 cells treated with MSA. "
3.	T-Cell Leukemia (Leukemia, T Cell) 06/11/2015 - "Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors."
4.	Neoplasm Metastasis (Metastasis) 09/15/2007 - "We have investigated the effect of methylseleninic acid (MSA) on tumor stage-specific prostate cells derived from the C3 (1)/Tag model for PrCa: Pr111, a slow-growing and nontumorigenic cell line isolated from a prostate intraepithelial neoplasia lesion; Pr14, a tumorigenic line derived from a primary tumor; and Pr14C1, a sub-clone of Pr14 explanted from a lung metastasis. "
5.	Infections 01/01/2021 - "Our results show promise toward developing highly potent HTLV-1 protease inhibitors as therapeutic agents against HTLV-1 infections."

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Proteins (Proteins, Gene)
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Neuropilin-1
5.	Pyrrolidines
6.	Lipids
7.	Allergens
8.	methylselenic acid