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GYKI 53655

an AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptor antagonist

Also Known As:

1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine; GYKI-53655; LY 300168

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        GYKI 53655: 6

Experts

1.	Ko, Shanelle W: 1 article (09/2005)
2.	Toyoda, Hiroki: 1 article (09/2005)
3.	Wu, Long-Jun: 1 article (09/2005)
4.	Zhao, Ming-Gao: 1 article (09/2005)
5.	Zhuo, Min: 1 article (09/2005)
6.	Ali, Afia B: 1 article (06/2003)
7.	Kleinrok, Z: 1 article (11/2001)
8.	Luchowska, E: 1 article (11/2001)
9.	Luchowski, P: 1 article (11/2001)
10.	Urbanska, E M: 1 article (11/2001)

Related Diseases

1.	Seizures (Absence Seizure) 04/16/1999 - "The occurrence of 3-nitropropionic acid-induced seizures was inhibited by the alpha-amino-2,3-dihydro-5-methyl-3-oxo-isoxazole-propionate (AMPA)/kainate receptor antagonists, 6-nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione disodium (NBQX) and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine HCI (GYKI 52466), with ED50 of 14.1 (7.9-25.2) and 7.2 (5.3-9.6) mg/kg, respectively. " 11/16/2001 - "In this study, we evaluated whether beta-adrenoceptor antagonists may modify the protective efficacy of dizocilpine (MK-801), a NMDA receptor antagonist, and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466), a non-NMDA (AMPA/kainate) receptor antagonist, against maximal electroshock-induced seizures in mice. "
2.	Shock 06/01/2003 - "EPSCs elicited in pyramidal and fast-spiking cells in layers 2/3 and 5 of the rat motor cortex by extracellular single shock stimulus in the presence of GYKI 53655 and D-2-amino-5-phosphopentanoic resulted in a residual current. " 10/01/1998 - "The AMPA receptor-selective allosteric antagonists GYKI 52466 (50 microM) and GYKI 53655 (50 microM) partially suppressed depolarizing synaptic responses evoked by single shock EC stimulation, but fully blocked synaptic responses evoked by BA stimulation. " 09/01/2005 - "Single-shock stimulation could induce small KA receptor-mediated excitatory postsynaptic currents (KA EPSCs) in the presence of picrotoxin, D-2-amino-5-phosphono-pentanoic acid, and a selective AMPA receptor antagonist, GYKI 53655. "
3.	Hypoxia (Hypoxemia) 10/01/1999 - "Using 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466), we tested the hypothesis that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are important controllers of cerebral O2 supply/consumption balance in newborn piglets during both normoxia and hypoxia. "

Related Drugs and Biologics

1.	GYKI 52466
2.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
3.	Kainic Acid Receptors (Kainate Receptor)
4.	Dizocilpine Maleate (Dizocilpine)
5.	N-Methylaspartate (NMDA)
6.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
7.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)
8.	AMPA Receptors (AMPA Receptor)
9.	Quinoxalines
10.	Picrotoxin