|1.||Boukes, Gerhardt J: 2 articles (12/2012 - 01/2010)|
|2.||van de Venter, Maryna: 2 articles (12/2012 - 01/2010)|
|3.||Ali Azouaou, Sarah: 1 article (02/2015)|
|4.||Fuhrmann, Guy: 1 article (02/2015)|
|5.||Muller, Christian D: 1 article (02/2015)|
|6.||Idris-Khodja, Noureddine: 1 article (02/2015)|
|7.||Schini-Kerth, Valérie: 1 article (02/2015)|
|8.||Emhemmed, Fathi: 1 article (02/2015)|
|9.||Lobstein, Annelise: 1 article (02/2015)|
|10.||Daniels, Brodie B: 1 article (01/2010)|
02/01/2015 - "We therefore analyzed the antineoplastic activity of rooperol, the aglycone of the plant-derived compound hypoxoside, on a model of Oct4-expressing cancer stem-like cell, i.e. "
02/01/2015 - "Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells."
01/01/2010 - "IC50 values of hypoxoside and rooperol were determined against the HeLa, HT-29, and MCF-7 cancer cell lines, and peripheral blood mononuclear cells. "
09/01/1995 - "Morphological characterisation of the cell-growth inhibitory activity of rooperol and pharmacokinetic aspects of hypoxoside as an oral prodrug for cancer therapy."
09/01/1999 - "Elevated collagen synthesis and deposition could impede tumour cell invasion and metastasis, implying that rooperol may be useful as an antimetastatic agent in the treatment of cancer."
|2.||Neoplasm Metastasis (Metastasis)
|4.||Melanoma (Melanoma, Malignant)
09/01/1995 - "The supernatant of a human melanoma homogenate could also cause deconjugation of the metabolites to form rooperol.(ABSTRACT TRUNCATED AT 250 WORDS)"
09/01/1995 - "Rooperol metabolites isolated from human urine were non-toxic for BL6 melanoma cells in culture up to a concentration of 200 micrograms/ml. In the presence of beta-glucuronidase, which released rooperol from the metabolites, 50% growth inhibition was achieved at a 75 micrograms/ml metabolite concentration. "
09/01/1995 - "The latter catalyses hypoxoside conversion to its cytotoxic aglucone, rooperol, which, when tested as a pure chemical, caused 50% inhibition of BL6 melanoma cell growth at 10 micrograms/ml. Light and electron microscopy revealed that the cytotoxic effect of rooperol manifested as vacuolisation of the cytoplasm and formation of pores in the plasma membrane. "
|2.||Interleukin-1beta (Interleukin 1 beta)
|3.||Oxidants (Oxidizing Agents)
|4.||Interleukin-6 (Interleukin 6)
|5.||Phytosterols (Plant Sterols)
|8.||Dihydrotachysterol (AT 10)