Abbott 77003

a symmetry-based inhibitor of HIV-1 protease

Also Known As:

(2(S),5(S))-1,2,5,6-Tetradeoxy-2,5-bis((3-methyl-2-(((methyl(2-pyrimidinylmethyl)amino)carbonyl)amino)-1-oxobutyl)amino)-1,6-diphenyl-L-altritol; A 77003; A-77003; A77003; ABT 77003; ABT-77003; Abbott A77003

Networked: 5 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Methylurea Compounds
      - Abbott 77003: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Abbott 77003: 5
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - Abbott 77003: 5
  - Essential Amino Acids: 1152
    - Valine: 1999
      - Abbott 77003: 5

Related Diseases

1.	Infections 11/01/1995 - "Efficacy of constant infusion of A-77003, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, in limiting acute HIV-1 infection in vitro." 01/01/1993 - "A77003 was more effective in persistent HIV-1 infection than alpha and beta interferons (1,000 U/ml), while zidovudine and 2',3'-dideoxy-2',3'-didehydrothymidine were not active."
2.	Persistent Infection 03/01/1995 - "In vitro, A77003 is effective in both acute and chronic infection in 10% fetal bovine or human serum. " 11/01/1995 - "A-77003, a human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is effective for both acute and chronic infection in vitro and was evaluated clinically by continuous intravenous infusion administration. "
3.	Phlebitis 07/01/1995 - "In conclusion, A77003, as formulated in the present study, causes severe phlebitis, which prevents administration of the infusates necessary to achieve high concentrations of the drug in plasma. " 07/01/1995 - "In conclusion, A77003, as formulated in the present study, causes severe phlebitis, which prevents administration of the infusates necessary to achieve high concentrations of the drug in plasma. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 06/01/1994 - "These features of A77003 (and perhaps similar HIV protease inhibitors as well) anti-HIV activity should represent desirable properties for antiviral therapy of AIDS and related diseases."

Related Drugs and Biologics

1.	Zidovudine (Retrovir)
2.	Protease Inhibitors (Protease Inhibitor)
3.	Peptide Hydrolases (Proteases)
4.	Interferons
5.	HIV Protease Inhibitors
6.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics