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4- (benzodioxan- 5- yl)- 1- (indan- 2- yl)piperazine

Also Known As:

S 15535; S-15535; Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1H-inden-2-yl)-

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine: 4

Experts

1.	Koolhaas, Jaap M: 1 article (06/2004)
2.	Korte, S Mechiel: 1 article (06/2004)
3.	de Boer, Sietse F: 1 article (06/2004)
4.	van Hierden, Yvonne M: 1 article (06/2004)
5.	Gannon, R L: 1 article (01/2003)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2003 - "The large-magnitude phase shifts, and temporal-activity profile seen with BMY 7378 and S 15535, suggest that compounds with this unique pharmacological profile may be beneficial in the treatment of circadian phase delays recently reported to be a complication resulting from Alzheimer's disease."
2.	Hypothermia 01/05/1993 - "In vivo, S 15535 (0.16-10 mg/kg s.c.) acted as an antagonist at postsynaptic 5-HT1A receptors in completely blocking the flat-body posture and hypothermia elicited by the 5-HT1A receptor agonist, 8-OH-DPAT. " 01/01/1994 - "The spontaneous tail-flicks, flat-body posture and hypothermia mediated by an action of the 5-HT1A agonist 8-OH-DPAT at postsynaptic 5-HT1A receptors were dose-dependently and completely antagonized by S 14489, S 15535 and S15931 at doses of 0.63 to 10.0 and 2.5 to 40.0 mg/kg for s.c. "
3.	Body Weight (Weight, Body) 06/01/2004 - "Second, the most effective dose of S-15535 (4.0 mg/kg body weight) significantly increased severe feather-pecking behavior. "

Related Drugs and Biologics

1.	BMY 7378
2.	Serotonin 5-HT1 Receptor Agonists
3.	5-HT1A Serotonin Receptor
4.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
5.	S 15931
6.	S 14489
7.	hydroxide ion