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2,4-hexadienal

RN given refers to compound with no isomeric designation

Also Known As:

2,4-hexadienal, (E,E)-isomer; 2,4-hexadienal, (E,Z)-isomer

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - 2,4-hexadienal: 4
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        Alkadienes: 1
        2,4-hexadienal: 4

Experts

1.	National Toxicology Program: 1 article (10/2003)
2.	Chan, Po C: 1 article (09/2003)
3.	Lomnitski, Liat: 1 article (09/2003)
4.	Mahler, Joel: 1 article (09/2003)
5.	Nyska, Abraham: 1 article (09/2003)
6.	Peddada, Shyamal: 1 article (09/2003)
7.	Chan, P C: 1 article (12/2001)
8.	Lomnitski, L: 1 article (12/2001)
9.	Moomaw, C R: 1 article (12/2001)
10.	Nyska, A: 1 article (12/2001)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2003 - "Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice." 10/01/2003 - "2,4-Hexadienal was nominated for study by the National Cancer Institute because of the potential for carcinogenicity based on its alpha,beta-unsaturated aldehyde structure and the potential link between exposure to lipid peroxidation products in the diet and human malignancies. " 09/01/2003 - "2,4-Hexadienal (2,4-Hx) was studied for its toxicity and carcinogenicity because of its alpha, beta-unsaturated aldehyde structure and potential link between exposure to lipid peroxidation products in the diet and human malignancies. "
2.	Hyperplasia 10/01/2003 - "Hyperplasia of the forestomach in male and female rats and mice was associated with administration of 2,4-hexadienal. " 12/01/2001 - "2,4-Hexadienal (2,4-Hx), an unsaturated aldehyde formed by in vivo and in vitro peroxidation of unsaturated lipid induced, in National Toxicology Program (NTP) gavage studies of F344 rats, forestomach hyperplasia in 13-week and 2-year exposures and squamous papilloma and carcinoma in 2-year studies. "
3.	Squamous Cell Neoplasms (Squamous Cell Cancer) 10/01/2003 - "Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity* of 2,4-hexadienal in male and female F344/N rats and male and female B6C3F1 mice based on increased incidences of squamous cell neoplasms of the forestomach. "
4.	Papilloma (Papillomatosis) 12/01/2001 - "2,4-Hexadienal (2,4-Hx), an unsaturated aldehyde formed by in vivo and in vitro peroxidation of unsaturated lipid induced, in National Toxicology Program (NTP) gavage studies of F344 rats, forestomach hyperplasia in 13-week and 2-year exposures and squamous papilloma and carcinoma in 2-year studies. "
5.	Carcinoma (Carcinomatosis) 12/01/2001 - "2,4-Hexadienal (2,4-Hx), an unsaturated aldehyde formed by in vivo and in vitro peroxidation of unsaturated lipid induced, in National Toxicology Program (NTP) gavage studies of F344 rats, forestomach hyperplasia in 13-week and 2-year exposures and squamous papilloma and carcinoma in 2-year studies. "

Related Drugs and Biologics

1.	Aldehydes
2.	Lipids
3.	Glutathione S-Transferase pi
4.	n-pentanol