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patuletin

structure given in first source; inhibits aldose reductase in rat lens

Also Known As:

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4H-chromen-4-one

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        patuletin: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        patuletin: 9

Experts

1.	Bano, Samina: 3 articles (01/2019 - 05/2015)
2.	Faizi, Shaheen: 3 articles (01/2019 - 05/2015)
3.	Farooq, Ahsana Dar: 2 articles (01/2019 - 05/2015)
4.	Lubna,: 2 articles (07/2016 - 05/2015)
5.	Kim, Jang Hoon: 1 article (09/2022)
6.	Lee, Ik Soo: 1 article (09/2022)
7.	Al Bast, Nour Al Hoda: 1 article (08/2020)
8.	Borjac, Jamilah: 1 article (08/2020)
9.	Hodroj, Mohammad Hassan: 1 article (08/2020)
10.	Rizk, Sandra: 1 article (08/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/2017 - "The present study demonstrates that patuletin may be considered as a novel natural inhibitor of FASN, may induce anti-proliferative and pro-apoptotic effects in certain human breast cancer cells and may be useful for preventing and/or treating human breast cancer." 12/01/2017 - "The aim of the present study was to investigate the effects of patuletin on the gene expression and activity of FASN in the human breast cancer SK-BR-3 cell line, and the apoptotic effects of patuletin to breast cancer cells. " 12/01/2017 - "As a result, it was demonstrated that patuletin dose-dependently reduces FASN expression and intracellular activity in human breast cancer cells, and induces apoptosis in FASN over-expressing SK-BR-3 cells. " 12/01/2017 - "Patuletin induces apoptosis of human breast cancer SK-BR-3 cell line via inhibiting fatty acid synthase gene expression and activity."
2.	Neoplasms (Cancer) 08/28/2020 - "Furthermore, the chemical composition of UD aqueous extract indicated the presence of multiple chemical agents, such as flavonoids and phenolics, mainly patuletin, m/p-hydroxybenzoic acid, and caffeic acid, among others, to which the pro-apoptotic and anti-tumor effects may be attributed." 05/01/2015 - "patula flower methanol extract, its seven fractions, and three phenolic compounds including methyl protocatechuate (1), patuletin (2), and patulitrin (3) were evaluated using sulforhodamine-B assay against HeLa, HT-144, NCI-H460, MCF-7, PC-3, and SF-268 human cancer cell lines. "
3.	Melanoma (Melanoma, Malignant) 09/01/2022 - "We investigated the antimelanogenic effects of patuletin on B16F10 melanoma cells and zebrafish embryos. " 09/01/2022 - "Antimelanogenic activity of patuletin from Inula japonica flowers in B16F10 melanoma cells and zebrafish embryos."
4.	Inflammation (Inflammations) 01/01/2013 - "Patuletin and patulitrin were found to inhibit acute inflammation in mice. " 01/01/2013 - "Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. "
5.	Edema (Dropsy) 01/01/2013 - "Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. "

Related Drugs and Biologics

1.	Methanol (Carbinol)
2.	Fatty Acid Synthases (Fatty Acid Synthase)
3.	Luteolin
4.	Apigenin
5.	Flavones
6.	Flavonols
7.	Arachidonic Acid (Vitamin F)
8.	Sesquiterpenes
9.	Quercetin
10.	Lactones

Related Therapies and Procedures

1.	Topical Administration
2.	Oral Administration