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tau protein kinase II

involved in the regulation of tau protein kinase I, as well as directly phosporylating tau protein at serine and threonine residues

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Evans, D B: 2 articles (02/2001 - 08/2000)
2.	Sharma, S K: 2 articles (02/2001 - 08/2000)
3.	Evans, David B: 1 article (01/2002)
4.	Rank, Kenneth B: 1 article (01/2002)
5.	Sharma, Satish K: 1 article (01/2002)
6.	Lund, E T: 1 article (02/2001)
7.	Mathews, W R: 1 article (02/2001)
8.	McKenna, R: 1 article (02/2001)
9.	Bhattacharya, K: 1 article (08/2000)
10.	Gurney, M E: 1 article (08/2000)

Related Diseases

1.

Alzheimer Disease (Alzheimer's Disease)

01/04/2002 - "Dysregulation of the brain-specific tau protein kinase II (TPK II)/cdk5 is reported to play an important role in the pathogenesis of Alzheimer's disease. "
02/01/2001 - "Hyperphosphorylated tau is an integral part of the neurofibrillary tangles that form within neuronal cell bodies, and tau protein kinase II is reported to play a role in the pathogenesis of Alzheimer's disease. "
08/11/2000 - "Dysregulation of the brain-specific tau protein kinase II is reported to play an important role in the pathogenesis of Alzheimer's disease (Patrick, G. "
02/01/1993 - "Phosphorylation at Ser144 and at Thr147 of tau isolated from heat-stable brain extracts was shown to be developmentally regulated, with the highest level of phosphorylation found at postnatal week 1. In vitro phosphorylation of tau by tau protein kinase I, a kinase responsible for abnormal phosphorylation of tau found in paired helical filaments of patients with Alzheimer's disease, was enhanced by prior phosphorylation of tau by tau protein kinase II. Thus, we suggest that tau protein kinase II is indirectly involved, at least in part, in the regulation of the phosphorylation state of tau in neuronal cells."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	tau-protein kinase