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A 121

structure given in first source

Also Known As:

A-121; Antibiotic A121

Networked: 21 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - A 121: 21

Experts

1.	Adams, David J: 1 article (01/2021)
2.	Bishop, D Timothy: 1 article (01/2021)
3.	Brazma, Alvis: 1 article (01/2021)
4.	Corrie, Pippa: 1 article (01/2021)
5.	Couturier, Dominique-Laurent: 1 article (01/2021)
6.	Fonseca, Nuno A: 1 article (01/2021)
7.	Garg, Manik: 1 article (01/2021)
8.	Jönsson, Göran B: 1 article (01/2021)
9.	Lauss, Martin: 1 article (01/2021)
10.	Lo, Serigne: 1 article (01/2021)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2016 - "Whole genome microarray expression analysis using tumor and OSE-derived cell lines reveal a 121 gene signature associated with EMT and metastasis. " 01/01/2021 - "We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. " 01/01/2023 - "Mechanistically, circINSIG1 encoded a 121 amino acid protein circINSIG1-121 to promote K48-linked ubiquitination of the critical cholesterol metabolism regulator INSIG1 at lysine 156 and 158 by recruiting CUL5-ASB6 complex, a ubiquitin E3 ligase complex, thereby inducing cholesterol biosynthesis to promote CRC proliferation and metastasis. "
2.	Carcinoma (Carcinomatosis) 10/15/1989 - "Three intracellular isoenzyme forms A, I, and B, were isolated from invasive human ovarian carcinoma cell line A-121. " 09/09/1994 - "Adhesion of A-121 human ovarian carcinoma cells to extracellular matrix is partly mediated via interaction between galaptin, an endogenous beta-galactoside-binding lectin present in extracellular matrix, and specific cell surface carbohydrate receptors identified as lysosomal associated membrane proteins, lamp-1 and lamp-2. " 09/09/1994 - "In this study, we report that adhesion of human ovarian carcinoma cells to polystyrene plates coated with polymerized human splenic galaptin can be inhibited by polyclonal antibodies raised against lamp-1 and lamp-2 molecules and by pretreatment of A-121 human ovarian carcinoma cells with glucosamine analogs: 2-acetamido-1,4,6-tri-O-acetyl-3- deoxy-3-fluoro-alpha-D-glucopyranose (3-F-GlcNAc) and 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-alpha-D-glucopyranose (4-F-GlcNAc). "
3.	Overweight 01/01/2016 - "The present study was performed in a cohort of 298 patients including a) 121 overweight and obese patients, unaffected by hypertension or type 2 diabetes, b) 129 subjects affected by hypertension and not by type 2 diabetes, and c) 48 subjects affected by both hypertension and type 2 diabetes. "
4.	Melanoma (Melanoma, Malignant) 01/01/2021 - "We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. "
5.	Hypertension (High Blood Pressure) 01/01/2016 - "The present study was performed in a cohort of 298 patients including a) 121 overweight and obese patients, unaffected by hypertension or type 2 diabetes, b) 129 subjects affected by hypertension and not by type 2 diabetes, and c) 48 subjects affected by both hypertension and type 2 diabetes. "

Related Drugs and Biologics

1.	Galectin 1 (LGALS1)
2.	RNA (Ribonucleic Acid)
3.	Polystyrenes (Polystyrene)
4.	Glucosamine (Dona)
5.	Antibodies
6.	2- acetamido- 1,3,6- tri- O- acetyl- 4- deoxy- 4- fluoroglucopyranose
7.	Proteins (Proteins, Gene)
8.	Amino Acids
9.	Lysosomal Membrane Proteins
10.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)

Related Therapies and Procedures

1.	Segmental Mastectomy (Lumpectomy)
2.	Length of Stay