serotonin 5 receptor

has remarkable heterogeneity within the 5HT1D receptor family; 5A & 5B are two subtypes; amino acid sequence in first source

Also Known As:

5-HT5 receptor; 5-HT5A receptor; 5-hydroxytryptamine 5 receptor; 5HT5 receptor; 5HT5 receptors; 5HT5A receptor; 5HT5B receptor; receptor, 5HT5; receptor, serotonin 5A; receptor, serotonin 5B; serotonin 5A receptor; serotonin 5B receptor; serotonin receptor 5A; serotonin receptors 5A

Networked: 20 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125

Experts

1.	Harada, Katsuya: 3 articles (01/2018 - 10/2014)
2.	Okabe, Mayuko: 3 articles (01/2018 - 10/2014)
3.	Yamamoto, Noriyuki: 3 articles (01/2018 - 10/2014)
4.	Yamazaki, Mayako: 3 articles (01/2018 - 10/2014)
5.	Yarimizu, Junko: 3 articles (01/2018 - 10/2014)
6.	Collier, D A: 2 articles (05/2001 - 06/2000)
7.	Aarts, Craig: 1 article (08/2020)
8.	Al-Awar, Rima: 1 article (08/2020)
9.	Dvorkin-Gheva, Anna: 1 article (08/2020)
10.	Ford, Emily: 1 article (08/2020)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 07/01/2004 - "Family-based association studies between 5-HT5A receptor gene and schizophrenia." 08/01/2004 - "We also demonstrated a positive association between schizophrenia and a 5-HT5A receptor polymorphism, Pro15Ser, that may have role in cell differentiation in the brain." 01/01/2018 - "Our previous results suggest that 5-HT5A receptor antagonists may be effective against cognitive impairment in schizophrenia. " 08/01/2012 - "Consequently, further investigations are required to define the therapeutic potential of 5-HT5A receptor ligands in anxiety, depression and schizophrenia models." 03/01/2015 - "These results indicate that the 5-HT5A receptor is involved in learning and memory and that treatment with 5-HT5A receptor antagonists might be broadly effective for cognitive impairment associated with not only schizophrenia but also dementia. "
2.	Cognitive Dysfunction 01/01/2018 - "Our previous results suggest that 5-HT5A receptor antagonists may be effective against cognitive impairment in schizophrenia. " 01/01/2018 - "In this study, using behavioral, immunohistochemical, electrophysiological and microdialysis techniques, we examined the mechanism by which ASP5736, a novel and selective 5-HT5A receptor antagonist, exerts a positive effect in animal models of cognitive impairment. " 03/01/2015 - "These results indicate that the 5-HT5A receptor is involved in learning and memory and that treatment with 5-HT5A receptor antagonists might be broadly effective for cognitive impairment associated with not only schizophrenia but also dementia. " 10/01/2014 - "These results collectively suggest that ASP5736 is a novel and potent 5-HT5A receptor antagonist that not only ameliorates positive-like symptoms but also cognitive impairments in animal models of schizophrenia, without adverse effects. " 10/01/2014 - "ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia."
3.	Fragile X Syndrome (Martin Bell Syndrome) 01/01/2022 - "5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome."
4.	Dementia (Dementias) 03/01/2015 - "These results indicate that the 5-HT5A receptor is involved in learning and memory and that treatment with 5-HT5A receptor antagonists might be broadly effective for cognitive impairment associated with not only schizophrenia but also dementia. " 03/01/2015 - "Given that areas of the brain with high levels of 5-HT5A receptor expression, such as the hippocampus and cerebral cortex, have important functions in cognition and memory, we evaluated the chemically diverse, potent and brain-penetrating 5-HT5A receptor antagonists ASP5736, AS2030680, and AS2674723 in rodent models of cognitive dysfunction associated with dementia. "
5.	Mood Disorders (Mood Disorder) 05/04/2001 - "In the present study, genetic variation of the 5-HT5A receptor was analyzed in patients affected by affective disorders and healthy controls. " 05/04/2001 - "Our results suggest that the polymorphisms analyzed in the 5-HT5A receptor gene do not play a major role in the pathogenesis of affective disorders." 06/26/2000 - "We conclude that allelic variation in the human 5-HT5A receptor gene may be involved in susceptibility to schizophrenia and affective disorders but not in determining response to clozapine."

Related Drugs and Biologics

1.	N- (diaminomethylene)- 1- (3,5- difluoropyridin- 4- yl)- 4- fluoroisoquinoline- 7- carboxamide
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Ketamine
4.	Serotonin (5 Hydroxytryptamine)
5.	Ligands
6.	Scopolamine (Hyoscine)
7.	Phencyclidine (Angel Dust)
8.	Oxygen (Dioxygen)
9.	Metergoline
10.	Methamphetamine (Desoxyn)