|1.||Burch, Michael D: 2 articles (05/2015 - 01/2008)|
|2.||Song, Lirong: 2 articles (03/2014 - 02/2009)|
|3.||Moscow, Jeffrey A: 2 articles (01/2014 - 02/2007)|
|4.||Lürling, Miquel: 2 articles (03/2013 - 06/2003)|
|5.||Yu, S: 2 articles (03/2001 - 03/2001)|
|6.||Labine, Meaghan: 1 article (06/2015)|
|7.||Minuk, Gerald Y: 1 article (06/2015)|
|8.||Tseng, Jing-Hua: 1 article (05/2015)|
|9.||Chang, De-Wei: 1 article (05/2015)|
|10.||Huo, Xiangchen: 1 article (05/2015)|
|1.||Colorectal Neoplasms (Colorectal Cancer)
07/01/2005 - "It has been shown by epidemiological and animal studies that microcystin is an important exogenous factor involved in the carcinogenesis of colorectal cancer (CRC). "
06/01/2002 - "The types of drinking water are positively associated with the incidence of colorectal cancer in the study sites, and this may be related to microcystin contamination of drinking water. "
06/01/2002 - "Spearman rank correlation analysis showed that in the study sites, the microcystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs = 0.881, P < 0.01). "
07/01/2000 - "It is suggested that further study should be carried out to clarify the relationship between colorectal cancer and microcystin in drinking water."
06/01/2002 - "To investigate the association of microcystin (MC) in drinking water with the incidence of colorectal cancer. "
|2.||Liver Neoplasms (Liver Cancer)
01/01/2000 - "As in previous studies, high incidence of liver cancer coincided with high microcystin concentration in the source water, especially in pond water. "
01/01/1996 - "In order to study the pollution with microcystin (MC), a potent liver promoter, in drinking water in highly endemic area of liver cancer, cyanobacteria and its product MC were detected in drinking water in Haimen, Jiangsu Province during 1992 to 1993. "
01/01/1996 - "[Studies on microcystin contents in different drinking water in highly endemic area of liver cancer]."
10/01/2001 - "Microcystin in contaminated drinking water may be the cause of elevated rates of primary liver cancer in some areas of China. "
03/01/2001 - "[The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China]."
06/01/2015 - "Long-term, low-dose exposure to microcystin toxin does not increase the risk of liver tumor development or growth in mice."
03/01/2014 - "The widespread occurrence of these organisms, coupled with the tumor-promoting properties of the microcystin toxins that they produce, demands action to mitigate their potential impacts and, thus, a robust understanding of their ecological dynamics. "
01/01/2014 - "Microcystin variants have been isolated and tested for cytotoxicity in cancer cells stably transfected with OATP1B1 and OATP1B3 transporters. "
01/01/2014 - "Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells."
02/01/2008 - "These data suggest that regulation of the cell cycle by p53 is important in preventing the proliferative response associated with chronic, sublethal microcystin exposure, and therefore, conclude that p53 plays an important role in MCLR-induced tumor promotion."
|4.||Body Weight (Weight, Body)
06/01/2014 - "The bioaccumulation of microcystin in carp and catfish was negatively correlated with body weight, and showed species specificity. "
05/01/2014 - "Crayfish survival was 100% when fed freeze-dried Microcystis sp. incorporated into an artificial diet (6-100 μg microcystin kg(-1) ww) at dietary doses from 0.03 to 0.55 μg g(-1) body weight d(-1) for 27 days. "
04/01/2000 - "Trout had been gavaged with lyophilized cyanobacteria (Microcystis aeruginosa, strain PCC 7806) at acutely toxic doses of 5700 microg microcystin (MC) per kg of body weight (bw), as described previously (Tencalla and Dietrich, 1997). "
11/01/2006 - "To study the transcriptional response of liver genes to microcystin treatment, tilapia were respectively exposed to a single 50 microg kg(-1) body weight (bwt) dose of pure MC-LR, a single 2 mg kg(-1) bwt dose of LPS and a co-exposure MC-LR and LPS (50 microg kg(-1) bwt+2 mg kg(-1) bwt), and were then sacrificed at 24 h post-exposure. "
06/30/2012 - "Microcystin significantly decreased body length, while ammonia significantly increased body weight, specific growth rate, and condition factor, but there was no significant interaction between ammonia and microcystin on them. "
01/01/1991 - "These findings indicate the involvement of TNF in microcystin shock."
03/04/2009 - "Deaths from microcystin toxication have widely been attributed to hypovolemic shock due to hepatic interstitial hemorrhage, while some recent studies suggest that cardiogenic complication is also involved. "
04/01/2004 - "Our results illustrated the involvement of NO production, iNOS and some cytokines in mice immune system in microcystin shock."
01/01/1991 - "Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum."
|1.||Proteins (Proteins, Gene)
|3.||cyanoginosin LR (microcystin LR)
|7.||PTEN Phosphohydrolase (PTEN Phosphatase)
|9.||Small Interfering RNA (siRNA)