microcystin

06/01/2002 - "Spearman rank correlation analysis showed that in the study sites, the microcystin concentration of river and pond water was positively associated with the incidence of colorectal cancer (rs = 0.881, P < 0.01). "
07/01/2005 - "It has been shown by epidemiological and animal studies that microcystin is an important exogenous factor involved in the carcinogenesis of colorectal cancer (CRC). "
06/01/2002 - "The types of drinking water are positively associated with the incidence of colorectal cancer in the study sites, and this may be related to microcystin contamination of drinking water. "
07/01/2000 - "It is suggested that further study should be carried out to clarify the relationship between colorectal cancer and microcystin in drinking water."
06/01/2002 - "To investigate the association of microcystin (MC) in drinking water with the incidence of colorectal cancer. "

01/01/2017 - "Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study."
11/01/2020 - "The present report tests the hypothesis that early life exposure to microcystin (MC), a principal component of harmful algal blooms followed by a juvenile exposure to high-fat diet feeding potentiate the development of nonalcoholic fatty liver disease phenotype in adulthood. "
01/01/2020 - "Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis."
01/01/2019 - "With increased climate change pressures likely to influence harmful algal blooms, exposure to microcystin, a known hepatotoxin and a byproduct of cyanobacterial blooms can be a risk factor for NAFLD associated comorbidities. "
01/01/2019 - "Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease."

01/01/2000 - "As in previous studies, high incidence of liver cancer coincided with high microcystin concentration in the source water, especially in pond water. "
03/01/2001 - "[The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China]."
03/01/2001 - "Microcystin is a group of algae toxin which causes liver cancer. "
01/01/1996 - "In order to study the pollution with microcystin (MC), a potent liver promoter, in drinking water in highly endemic area of liver cancer, cyanobacteria and its product MC were detected in drinking water in Haimen, Jiangsu Province during 1992 to 1993. "
01/01/1996 - "[Studies on microcystin contents in different drinking water in highly endemic area of liver cancer]."

07/01/2002 - "To study the molecular mechanism of microcystin (MC) induced liver tumorigenesis in rats. "
07/01/2005 - "This implies that the constitutive activation of Akt and the p38, JNK of MAPK pathways in microcystin-transformed cells may be the mechanism by which this important external factor acts in the carcinogenesis of CRC."
07/01/2002 - "[The expression of bcl-2 and bax genes during microcystin induced liver tumorigenesis]."
07/01/2005 - "It has been shown by epidemiological and animal studies that microcystin is an important exogenous factor involved in the carcinogenesis of colorectal cancer (CRC). "
01/01/2018 - "Controlling the influx of Cyanobacteria-like particles or microcystin and the inhibition of PARP1 can provide a potential targeted therapy and prevention of inflammation-associated lung carcinogenesis."

02/01/2022 - "Microcystin, a cyanotoxin produced by Microcystis aeruginosa growing in eutrophic waters, can promote liver tumors in people ingesting contaminated water. "
01/01/2022 - "Cyanobacterial genes positively associated with HCC were specific to taxa producing microcystin, the hepatotoxic tumor promotor, and other genes known to be upregulated with microcystin exposure. "
10/01/2020 - "The results revealed that although the incidence rates for all three cancers have increased over the past 20-25 years, these increases were not disproportionally higher in zones with high microcystin toxin determinations. "
05/01/2019 - "Multifactorial COX regression analysis suggested that serum microcystin-LR ≥ 0.97 ng/ml was associated with the increased risk of the tumor relapse (HR: 1.53, 95% CI: 1.35-1.77) and serum microcystin-LR ≥ 1.09 ng/ml was related to the higher risk of the overall death (HR: 1.58, 95% CI: 1.35-1.84) in the follow-up period. "
04/15/2018 - "Recently, an article entitled "Long-term, low-dose exposure to microcystin toxin does not increase the risk of liver tumor development or growth in mice" was published in Hepatology Research by Meaghan Labine and Gerald Y. "