|1.||Casanova, Jean-Laurent: 7 articles (09/2010 - 03/2003)|
|2.||Casanova, J L: 7 articles (10/2001 - 01/2000)|
|3.||Holland, Steven M: 5 articles (08/2013 - 09/2004)|
|4.||Speck, Samuel H: 4 articles (01/2015 - 11/2005)|
|5.||Rojas, Mauricio: 4 articles (08/2010 - 11/2005)|
|6.||Mora, Ana L: 4 articles (08/2010 - 11/2005)|
|7.||Chapgier, Ariane: 4 articles (03/2010 - 03/2003)|
|8.||Kwon, O Jung: 4 articles (11/2007 - 04/2005)|
|9.||Koh, Won-Jung: 4 articles (11/2007 - 04/2005)|
|10.||Hwang, Jung Hye: 4 articles (11/2007 - 04/2005)|
08/01/1997 - "Within the past year, highlights include the mapping of a locus controlling the intensity of infection by Schistosoma mansoni, the demonstration that mutations in the interferon-gamma receptor 1 gene are causative of disseminated infection due to weakly pathogenic mycobacteria, and the identification, in the CCR5 gene, of a deletion which provides high protection against HIV-1 infection. "
08/01/1997 - "IFN-gammaR(-/-) mice cleared an infection with CS100 but were significantly more susceptible than control littermates to infection with C231 or TB521. "
12/01/2000 - "Infection in 129 mice was cleared between days 21 and 28 postchallenge, whereas infection in IFN-gammaR(-) mice was evident in 100% of animals from day 21 onward. "
08/03/1998 - "MCMV-infected IFN-gammaR-/- mice shed preformed infectious MCMV in spleen, peritoneal exudate cells, and salivary gland for up to 6 mo after infection, whereas the majority of congenic control animals cleared chronic productive infection. "
06/01/2006 - "In this study, we demonstrate that a lack of IFN-gamma production or signaling results in increased vulnerability to lethal WNV infection by a subcutaneous route in mice, with a rise in mortality from 30% (wild-type mice) to 90% (IFN-gamma(-/-) or IFN-gammaR(-/-) mice) and a decrease in the average survival time. "
05/01/2003 - "We show in this study that CD8(+) effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-gammaR. "
03/01/2010 - "A defect in IFN-gammaR increased tumor growth, whereas tumor growth was inhibited in mice that were deficient in both IL-17R and IFN-gammaR compared with wild-type animals. "
10/15/2008 - "We observed that fewer NK cells infiltrated the tumors in IFN-gamma receptor knockout (IFN-gammaR(-/-)) mice compared with wild-type controls that correlated with decreased survival rate. "
01/15/2008 - "These findings suggest that coordinate downregulation of Fas and IFN-gammaR, 2 key components of cancer immunosurveillance system on tumor cells, leads to a more aggressive metastatic phenotype."
01/15/2008 - "Interestingly, disruption of IFN-gammaR function did not alter tumor cell susceptibility to CTL-mediated cytotoxicity, but is linked to enhanced infiltration of endogenous T cells in the tumor microenvironment in vivo. "
|3.||Communicable Diseases (Infectious Diseases)
01/25/2002 - "To our knowledge, this is the first report of adenovirus-mediated IFN-gammaR gene transfer being effective in augmenting the biological activity of IFN-gamma, and the strategy employed in the present study will be useful in studying other kinds of cytokine receptors and applications to gene therapy for cancer and infectious diseases."
01/01/2005 - "We concluded that CXCL12 plays a central role in the pathogenesis of CIA in IFN-gammaR KO mice by promoting delayed type hypersensitivity against the auto-antigen and by interfering with chemotaxis of CXCR4+ cells to the inflamed joints. "
01/01/2001 - "Similarly, cutaneous delayed-type hypersensitivity, a typical Th1 response, was abolished in the IL-12-/-, mice but increased in the IFN-gammaR-/- mice. "
05/12/2009 - "Here we show that in naive animals spinal microglia express a receptor for the cytokine IFN-gamma (IFN-gammaR) in a cell-type-specific manner and that stimulating this receptor converts microglia into activated cells and produces a long-lasting pain hypersensitivity evoked by innocuous stimuli (tactile allodynia, a hallmark symptom of neuropathic pain). "
08/01/2000 - "Delayed type hypersensitivity-associated cytokines in islet xenotransplantation: limited efficacy of interleukin-2- and tumor necrosis factor-alpha-blockade in interferon-gamma receptor-deficient mice."
10/01/2008 - "We studied the polymorphisms in the interferon (IFN)-gamma (gamma) and IFN-gamma receptor 1 (IFNR1) gene with the aim of clarifying the relationships among these polymorphisms, penicillin allergy and anti-penicillin antibodies. "
07/01/2008 - "Thus, in the absence of IFN-gammaR signaling, MHV-68 initiates a Th2 immune response, leading to alternative activation of macrophages and induction of fibrosis. "
07/01/2008 - "We show here that by Day 12 postinfection, prior to development of fibrosis in the spleens of IFN-gammaR-/- mice, different subsets of splenic macrophages (Mvarphis) are morphologically activated and enter latently infected germinal centers (GCs). "
05/01/2005 - "Schistosomal hepatic fibrosis and the interferon gamma receptor: a linkage analysis using single-nucleotide polymorphic markers."
01/01/2015 - "A small animal model of multi-organ fibrosis, which involves murine gammaherpesvirus (MHV68) infection of interferon gamma receptor deficient (IFNγR-/-) mice, has been utilized to model the association of gammaherpesvirus infections and lung fibrosis. "
07/01/2008 - "Infection of mice deficient in IFN-gammaR signaling (IFN-gammaR-/-) results in a multiple organ fibrosis, in which the spleen is severely affected. "
|1.||Interferon-gamma (Interferon, gamma)
|2.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|3.||Cytokine Receptors (Cytokine Receptor)
|5.||Nitric Oxide (Nitrogen Monoxide)
|7.||Interleukin-12 (IL 12)
|9.||adjuvant P40 (P 40)
|10.||Interleukin-12 Receptors (Interleukin 12 Receptor)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Investigational Therapies (Experimental Therapy)
|4.||Hematopoietic Stem Cell Transplantation
|5.||Bone Marrow Transplantation (Transplantation, Bone Marrow)