omega-3 fatty acid desaturase

catalyzes desaturation of the omega-3 carbon (3rd from free end) of C-18 fatty acids; deficiency results in accumulation of linoleic acid (18:2omega6,9) at the expense of linolenic acid (18:3omega3,6,9)

Also Known As:

omega-3 desaturase

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Fatty Acid Desaturases: 159
        omega-3 fatty acid desaturase: 6

Experts

1.	Berquin, Isabelle M: 2 articles (02/2012 - 07/2007)
2.	Chen, Yong Q: 2 articles (02/2012 - 07/2007)
3.	Edwards, Iris J: 2 articles (02/2012 - 07/2007)
4.	Wu, Jiansheng: 2 articles (02/2012 - 07/2007)
5.	Axanova, Linara S: 1 article (02/2012)
6.	Cai, Jiaozhong: 1 article (02/2012)
7.	Cramer, Scott D: 1 article (02/2012)
8.	Gu, Zhennan: 1 article (02/2012)
9.	Loda, Massimo F: 1 article (02/2012)
10.	Mucci, Lorelei A: 1 article (02/2012)

Related Diseases

1.	Wounds and Injuries (Trauma) 02/10/2010 - "Omega-3 fatty acid desaturase genes isolated from purslane (Portulaca oleracea L.): expression in different tissues and response to cold and wound stress." 04/30/2002 - "A wound-inducible Arabidopsis plastid omega-3 fatty acid desaturase (fad7) cDNA was obtained. " 06/29/2000 - "Possible involvement of protein phosphorylation in the wound-responsive expression of Arabidopsis plastid omega-3 fatty acid desaturase gene."
2.	Neoplasms (Cancer) 10/01/2010 - "Mice containing double mutations (DM) in c-myc and TGF-alpha (transforming growth factor-alpha), leading to liver neoplasia, were crossed with mice containing omega-3 desaturase. " 07/01/2007 - "Introducing an omega-3 desaturase, which converts omega-6 to omega-3 fatty acids, into the Pten-knockout mice reduced tumor growth similarly to the omega-3 diet. "
3.	Prostatic Neoplasms (Prostate Cancer) 02/01/2012 - "Cell culture, patient tissue microarray, allograft, xenograft, prostate-specific Pten knockout and omega-3 desaturase transgenic mouse models in conjunction with dietary manipulation, gene knockdown and knockout approaches were used to determine the effect of dietary PUFA on castration-resistant Pten-null prostate cancer. "

Related Drugs and Biologics

1.	Complementary DNA (cDNA)
2.	Transforming Growth Factor alpha (TGF-alpha)
3.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
4.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Castration