totarol

structure given in first source; isolated from the bark of Podocarpus nagi

Also Known As:

14-isopropylpodocarpa-8,11,13-trien-13-ol; 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-2-phenanthrenol

Networked: 10 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Abietanes: 39
        totarol: 10
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        Abietanes: 39
        totarol: 10
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Abietanes: 39
      - totarol: 10

Experts

1.	Huang, Lunhua: 2 articles (03/2021 - 03/2019)
2.	Jiang, Biao: 2 articles (03/2021 - 03/2019)
3.	Liu, Hongsheng: 2 articles (03/2021 - 03/2019)
4.	Liu, Zhiqiang: 2 articles (03/2021 - 03/2019)
5.	Lu, Xinyang: 2 articles (03/2021 - 03/2019)
6.	Ma, Dongwen: 2 articles (03/2021 - 03/2019)
7.	Ning, Xiaofei: 2 articles (03/2021 - 03/2019)
8.	Xu, Tong: 2 articles (03/2021 - 03/2019)
9.	Zhang, Guowei: 2 articles (03/2021 - 03/2019)
10.	Krajewski, Stefanie: 2 articles (05/2020 - 01/2016)

Related Diseases

1.	Infarction (Infarctions) 12/01/2015 - "In a model of acute cerebral ischemic injury in Sprague-Dawley rats, produced by occlusion of the middle cerebral artery for 2h followed by 22 h or 46 h of reperfusion, totarol significantly reduced infarct volume and improved the neurological deficit. "
2.	Bacterial Infections (Bacterial Infection) 01/01/2016 - "The PLGA microspheres characterized by slow release of totarol and great entrapment efficiency represent a novel drug delivery system, which may be highly beneficial for the long-term therapy of bacterial infections."
3.	Ischemic Stroke 12/01/2015 - "Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction." 12/01/2015 - "These observations suggest that totarol may be a novel activator of the Akt/HO-1 pathway protecting against ischemic stroke through reduction of oxidative stress."
4.	Stomach Neoplasms (Stomach Cancer) 03/01/2019 - "The results indicated that totarol induced selective cytotoxic effects in SGC-7901 human gastric cancer cells concentration-dependently and exhibited lower toxicity in GES-1 normal cells. " 03/01/2019 - "Therefore, the present research work was designed to evaluate the antitumor effects of totarol in SGC-7901 human gastric cancer cells and human gastric epithelial mucosa cell line GES-1 (used as normal cell line model) together with examining its effects on induction of apoptosis, cell cycle phase distribution and cell migration. " 03/01/2019 - "The present study indicated that totarol diterpene has the tendency to show selective anticancer effects in SGC-7901 human gastric cancer cells along with inducing apoptosis, cell cycle arrest and inhibition of cell migration."
5.	Neoplasms (Cancer) 03/01/2021 - "Retraction of: 'Totarol, a natural diterpenoid, induces selective antitumor activity in SGC-7901 human gastric carcinoma cells by triggering apoptosis, cell cycle disruption and suppression of cancer cell migration', by Tong Xu, Lunhua Huang, Zhiqiang Liu, Dongwen Ma, Guowei Zhang, Xiaofei Ning, Xinyang Lu, Hongsheng Liu, Biao Jiang JBUON 2019;24(2):686-692; PMID:31128024. " 03/01/2021 - "Totarol, a natural diterpenoid, induces selective antitumor activity in SGC-7901 human gastric carcinoma cells by triggering apoptosis, cell cycle disruption and suppression of cancer cell migration." 03/01/2019 - "Totarol, a natural diterpenoid, induces selective antitumor activity in SGC-7901 human gastric carcinoma cells by triggering apoptosis, cell cycle disruption and suppression of cancer cell migration." 09/01/2004 - "Two new diterpene anticancer constituents termed nootkastatins 1 (4) and 2 (5) were isolated along with three previously known diterpene cancer cell growth inhibitors where two were reported as synthetic modifications of totarol and not previously found in nature. "

Related Drugs and Biologics

1.	Diterpenes
2.	Dental Implants (Dental Implant)
3.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
4.	Hemolysin Proteins (Hemolysins)
5.	Growth Inhibitors
6.	Enterotoxins (Enterotoxin)

Related Therapies and Procedures

1.	Therapeutics
2.	Microspheres (Microsphere)