CGS 22652

has thromboxane receptor antagonism combined with thromboxane synthase inhibition; structure given in first source

Also Known As:

8-(((4-chlorophenyl)sulfonyl)amino)-4-(3-(3-pyridinyl)propyl)octanoic acid; 8-((4-chlorophenylsulfonyl)amino)-4-(3-(3-pyridinyl)propyl)octanoic acid; 8-CSAPOA; CGS-22652

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abran, D: 1 article (06/2001)
2.	Almazan, G: 1 article (06/2001)
3.	Beauchamp, M H: 1 article (06/2001)
4.	Chemtob, S: 1 article (06/2001)
5.	Gobeil, F: 1 article (06/2001)
6.	Hou, X: 1 article (06/2001)
7.	Lachapelle, P: 1 article (06/2001)
8.	Marrache, A M: 1 article (06/2001)
9.	Martinez-Bermudez, A K: 1 article (06/2001)
10.	Quiniou, C: 1 article (06/2001)

Related Diseases

1.	Hyperoxia 09/01/1998 - "The response to hyperoxia was attenuated 46+/-6 (n=6; P=0.001) after intravitreal CGS 22652 (2 nmol), a combined thromboxane synthesis inhibitor and receptor antagonist. " 06/01/2001 - "Hyperoxia-induced retinal vasoobliteration in rat pups (80% O2 exposure from postnatal days 5-14) was associated with increased TxB2 generation and was significantly prevented by TxA2 synthase inhibitor CGS-12970 (10 mg x kg(-1) x day(-1)) or TxA2-receptor antagonist CGS-22652 (10 mg x kg(-1) x day(-1)). "
2.	Renovascular Hypertension (Goldblatt Syndrome) 11/01/1994 - "To evaluate the contribution of thromboxane (Tx) A2-prostaglandin (PG) H2 in two-kidney, one-clip Goldblatt hypertension (GH), 26 GH rats were chronically treated (GHT) with a specific TxA2-PGH2 receptor antagonist, CGS-22652 (30 mg.kg-1.24 h-1 sc); 28 others as well as 17 sham-clipped (SC) rats received vehicle. "
3.	Coronary Thrombosis 05/12/1993 - "Beneficial effects of combined thromboxane synthase inhibition/receptor blockade with CGS 22652 in a canine model of coronary thrombosis."

Related Drugs and Biologics

1.	Thromboxanes
2.	Retinaldehyde (Retinal)
3.	3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid
4.	salicylhydroxamic acid (SHAM)

Related Therapies and Procedures

1.	Surgical Instruments (Clip)