|1.||Cintra, Adélia C O: 3 articles (05/2015 - 01/2014)|
|2.||Giglio, J R: 3 articles (01/2014 - 08/2004)|
|3.||Sampaio, Suely V: 2 articles (01/2015 - 09/2005)|
|4.||Soares, A M: 2 articles (01/2014 - 08/2004)|
|5.||Oshima-Franco, Yoko: 2 articles (01/2014 - 06/2002)|
|6.||Soares, Andreimar M: 2 articles (09/2005 - 06/2002)|
|7.||Giglio, José R: 2 articles (09/2005 - 06/2002)|
|8.||Tavares-Henriques, Matheus S: 1 article (05/2015)|
|9.||Monteiro-Machado, Marcos: 1 article (05/2015)|
|10.||Borges, Paula A: 1 article (05/2015)|
06/01/2002 - "Preincubating BthTX-I with Mn(2+) (1.0mM) reduced mouse paw edema by 70% and myotoxicity by 60% in mice injected i.m. "
06/01/2002 - "Among eight divalent cations assayed, Mn(2+) was the most effective in reducing mouse paw edema induced by BthTX-I (25 microg). "
08/01/2004 - "In this study, we demonstrate that CA significantly inhibits the edema induced by BthTX-I (23% inhibition), BthTX-II (27%), PrTX-I (25%), PrTX-III (35%) and MjTX-II (10%) on the mouse paw. "
01/01/2014 - "Alkylation reduced BthTX-II activity by 50% while this process abolished the catalytic and myotoxic activities of BthTX-I, while reducing its edema-inducing activity by about 50%. "
09/01/2005 - "RA inhibited the edema and myotoxic activity induced by the basic PLA2s BthTX-I and BthTX-II. It was, however, less efficient to inhibit the PLA2 activity of BthTX-II and, still less, the PLA2 and edema-inducing activities of the acidic isoform BthA-I-PLA2 from the same venom, showing therefore a higher inhibitory activity upon basic PLA2s. "
01/15/2005 - "However, when tissues were submitted to BthTX-I (10 degrees C for 60 min), and the temperature was elevated to 35 degrees C, omitting the washing step, it was observed muscle paralysis and damage in 39.04+/-4.2% of muscle fibers. "
01/15/2005 - "After 90 min at 35 degrees C, BthTX-I induced complete and irreversible paralysis, and damaged 30.3+/-2.7% of muscle fibers. "
01/15/2005 - "Besides inducing severe myonecrosis, BthTX-I promotes paralysis of both directly and indirectly evoked contractions in isolated neuromuscular preparations. "
01/01/2014 - "An isoflavone from Dipteryx alata Vogel is active against the in vitro neuromuscular paralysis of Bothrops jararacussu snake venom and bothropstoxin I, and prevents venom-induced myonecrosis."
01/01/2005 - "Histological analysis of soleus muscle after incubation with AE (400 microg/ml, 1 h) did not reveal any change in muscle fibers, but severe necrosis induced by BV or toxins (20 microg/ml) was clearly in evidence, and decreased significantly when soleus muscle was protected by AE. This protection was also observed when AE was administered 1 h after BV or BthTX-I, but not after BthTX-II. AE did not inhibit the catalytic PLA2 activity of BthTX-II or BV and did not change the PAGE pattern of BV, BthTX-I or BthTX-II. In vivo assays were performed in 100-g rats and maximal CK release was attained at a dose of 100 microg of BV, 3 h after injection. "
01/01/2015 - "Flow cytometry technique was used for the analysis of cell cycle alterations and death mechanisms (apoptosis and/or necrosis) induced in tumor cells after treatment with BthTX-I. It was observed that BthTX-I was cytotoxic to all evaluated tumor cell lines, reducing their viability in 40 to 50 %. "
|4.||Snake Bites (Snake Bite)
|4.||Snake Venoms (Snake Venom)
|7.||fucosylated chondroitin sulfate