|1.||An, Li-Jia: 11 articles (03/2013 - 10/2004)|
|2.||Jiang, Bo: 11 articles (03/2013 - 12/2006)|
|3.||Bao, Yong-Ming: 7 articles (08/2008 - 10/2004)|
|4.||An, Lijia: 5 articles (04/2010 - 05/2008)|
|5.||Li, Dan-Qing: 5 articles (01/2010 - 10/2004)|
|6.||Zhang, Xiuli: 4 articles (08/2013 - 06/2008)|
|7.||Bi, Jing: 4 articles (03/2013 - 09/2008)|
|8.||Wan, Dong: 3 articles (01/2013 - 12/2009)|
|9.||Bao, Yongming: 3 articles (09/2009 - 05/2008)|
|10.||Zhang, Aihong: 3 articles (09/2009 - 06/2008)|
|1.||Neurodegenerative Diseases (Neurodegenerative Disease)
01/01/2015 - "Catalpol: a potential therapeutic for neurodegenerative diseases."
01/01/2016 - "The results of the present study indicate that catalpol may be a potential drug for the treatment of neurodegenerative diseases such as AD. "
06/01/2008 - "Catalpol may be a potential anti-aging agent and worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's and Parkinson's diseases."
11/01/2012 - "Catalpol is a Chinese herb ingredient with potential for the treatment of neurodegenerative disorders. "
03/01/2009 - "The current results suggest that catalpol is a potential agent for the prevention of neurons apoptosis by regulating NO and iNOS increase in ERK-mediated neurodegenerative disorders."
01/01/2016 - "The present study revealed a novel effect of catalpol on vascular permeability and gave insight into the multifaceted roles of catalpol in inflammation. "
09/01/2009 - "The aim of this study was to investigate whether catalpol could facilitate recovery from lipopolysaccharide (LPS)-induced cognitive deficits and protect brain mitochondrial function from LPS-induced acute systemic inflammation. "
01/01/2015 - "Catalpol, an iridoid glucoside contained richly in the roots of the small flowering plant species Rehmannia glutinosa Libosch, has been shown to have antioxidation, anti-inflammation, anti-apoptosis and other neuroprotective properties and plays a role in neuroprotection against hypoxic/ischemic injury, AD and PD in both in vivo and in vitro models. "
04/29/2014 - "Treatment with catalpol significantly suppressed white matter inflammation and attenuated oligodendrocyte apoptosis and myelin damage. "
04/01/2013 - "Our findings indicate that catalpol suppresses AGE-mediated inflammation by inhibiting ROS production and NF-κB activity. "
|3.||Alzheimer Disease (Alzheimer's Disease)
01/01/2016 - "The present study assessed whether catalpol had any protective effects against Alzheimer's disease using a murine model. "
01/01/2016 - "Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice."
09/01/2014 - "To investigate the regulating effects of catalpol on the hypothalamic-pituitary- adrenocortical-axis (HPA) in an Alzheimer's disease (AD) rat model. "
09/01/2014 - "Catalpol regulates function of hypothalamic-pituitary-adrenocortical-axis in an Alzheimer's disease rat model."
08/01/2013 - "Thus catalpol is worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's disease."
12/15/2005 - "The neuroprotective efficacy of catalpol became more evident when the doses of catalpol were increased to 5 and 10mg/kg. In addition, it was exciting that the significant neuroprotection by catalpol was also evident when catalpol was applied up to 3 h after ischemia. "
12/17/2004 - "The neuroprotective efficacy of catalpol became more evident at the doses of 5 and 10 mg/kg. Of great importance were the findings that the neuroprotective efficacy of catalpol still could be seen even when the treatment was delayed 3 h and when the observational period was lasted out 35 days after ischemia. "
12/15/2005 - "But the neuroprotective efficacy of catalpol became weak when catalpol was given at 6h after ischemia. "
05/01/2008 - "Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage."
02/01/2008 - "However, the mechanism that catalpol prevents ischemia is still unclear. "
09/01/2014 - "The results showed that catalpol significantly improved the stroke index compared with CI/R control group (P < 0.05 or P < 0.01). "
08/01/2014 - "The results showed that catalpol significantly improved the stroke index compared with sham group (P < 0.05 or P < 0.01). "
01/01/2014 - "This research focused on effect of anti-stroke by lyophilized powder of catalpol and puerarin (C-P) and potential mechanisms. "
01/01/2013 - "Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice. "
01/01/2010 - "To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. "
|1.||NF-kappa B (NF-kB)
|3.||Taurocholic Acid (Sodium Taurocholate)
|4.||salicylhydroxamic acid (SHAM)
|6.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|10.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)