high MW hemorrhagic metalloprotease from Bothrops jararaca venom; 421-amino acid residue; contains disintegrin family with the Arg-Gly-Asp sequence replaced by Glu-Cys-Asp; jaracetin is an alternatively processed form of jararhagin; amino acid sequence given in first source
Also Known As:
HF2 -proteinase; jaracetin
Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Moura-da-Silva, Ana M: 5 articles (09/2012 - 06/2002)
2. Baldo, Cristiani: 3 articles (09/2015 - 01/2010)
3. Escalante, Teresa: 3 articles (09/2005 - 11/2003)
4. Ruiz, Itamar Romano Garcia: 2 articles (01/2014 - 01/2011)
5. Maria, Durvanei Augusto: 2 articles (01/2014 - 01/2011)
6. Maria, Durvanei A: 2 articles (12/2006 - 06/2002)
7. Juliano, Maria Aparecida: 2 articles (11/2006 - 01/2004)
8. Dale, Camila Squarzoni: 2 articles (11/2006 - 01/2004)
9. Giorgi, Renata: 2 articles (11/2006 - 01/2004)
10. Juliano, Luiz: 2 articles (11/2006 - 01/2004)

Related Diseases

1. Melanoma (Melanoma, Malignant)
2. Neoplasm Metastasis (Metastasis)
3. Snake Bites (Snake Bite)
4. Hemorrhage
5. Inflammation
12/15/2006 - "Jararhagin is a metalloproteinase from Bothrops jararaca responsible for hemorrhage, inflammation, necrosis and edema. "
11/01/2003 - "The jararhagin toxin, from Bothrops jararaca snake venom, acts upon several biological processes, as inflammation, pain, platelet aggregation, etc. In this article, the systemic effects of intra-peritoneal injections of different jararhagin doses were determined in mice. "
01/01/2014 - "Jararhagin toxin, a metalloproteinase isolated from Bothrops jararaca snake venom acts upon several biological processes, as inflammation, pain, platelet aggregation, proliferation and apoptosis, though not yet approved for use, may one day be employed to treat tumors. "
06/15/2005 - "Although hemorrhage and edema are a response to the direct effect of jararhagin, jararhagin-induced inflammation and necrosis are dependent on macrophages and key pro-inflammatory cytokines or their receptors. "
09/01/2005 - "The changes in gene expression observed by qRT-PCR on laser microdissected mouse muscle tissue treated with jararhagin were similar with significant up-regulation of proinflammatory transcripts such as IL-1 beta, IL-6, CXCL1, CXCL2, IL-8, and apoptosis, inflammation responsive transcripts such as TNF-alpha induced protein 6. Proteolytically inactive jararhagin had no effect on the gene expression profile of fibroblasts, indicating proteolysis as the primary mechanism affecting gene expression of cells and tissues resulting in a proinflammatory, pro-apoptotic host response which likely exacerbates the local necrosis frequently observed at the site of envenoming."

Related Drugs and Biologics

1. Snake Venoms (Snake Venom)
2. Metalloproteases (Metalloproteinases)
3. Venoms
4. Cytokines
5. Interleukin 1 Receptor Antagonist Protein (Anakinra)
6. Interleukin-1beta (Interleukin 1 beta)
7. Type II Tumor Necrosis Factor Receptors
8. Type I Tumor Necrosis Factor Receptors
9. Collagen Type IV (Type IV Collagen)
10. GTP Phosphohydrolases (GTPases)

Related Therapies and Procedures

1. Lasers (Laser)
2. Injections